TUTCRIS - Tampereen teknillinen yliopisto

TUTCRIS

A Sustainable Protocol for the Aqueous Multicomponent Petasis Borono-Mannich Reaction

Tutkimustuotosvertaisarvioitu

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut799-802
Sivumäärä4
JulkaisuJournal of Chemical Education
Vuosikerta89
Numero6
DOI - pysyväislinkit
TilaJulkaistu - kesäkuuta 2012
OKM-julkaisutyyppiA1 Alkuperäisartikkeli

Tiivistelmä

A protocol for the preparation of Petasis borono Mannich products suitable for advanced organic chemistry experiments, using water as a reaction medium, was developed. The experiment is carried out in less than 4 h (with a 30 min pre-session on the day before) using commercially available starting materials in the preparation of phenylglycine and 2-hydroxymorpholine derivatives. These experiments are useful in the organic chemistry curriculum for the introduction of multicomponent reactions and for the use of boronic acids and water as environmentally friendly reagents and solvent, respectively.

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