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Aberrantly binding microRNAs and their interactions with nuclear hormone receptors

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Aberrantly binding microRNAs and their interactions with nuclear hormone receptors. / Kandhavelu, Jeyalakshmi; Palanivel, Suresh; Kandhavelu, Meenakshisundaram.

julkaisussa: MicroRNA, 24.07.2017.

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Kandhavelu, Jeyalakshmi ; Palanivel, Suresh ; Kandhavelu, Meenakshisundaram. / Aberrantly binding microRNAs and their interactions with nuclear hormone receptors. Julkaisussa: MicroRNA. 2017.

Bibtex - Lataa

@article{fe649c2898a04ac6be24e9cdf80c0e22,
title = "Aberrantly binding microRNAs and their interactions with nuclear hormone receptors",
abstract = "Nuclear Hormone Receptors (NHRs) are the most important targets that plays vital role in cellular signaling pathways of disease. Regulation of NHRs by using potential non-coding RNAs, miRNA, is clinically important to control a disease. However, the detailed status of miRNA interactions with NHRs remains unclear. Hence, the focus of present study is to investigate the interface at the genome-wide level in human, mouse and rat using computational biology approach. This big-data analysis explored thousands of available miRNAs interactions with the NHRs and the results showed that 11 miRNAs have conserved targets, where six miRNAs genetically conserved among different species. This implies that both conserved and non-conserved miRNAs have a potential role in NHRs regulation. We found several {"}Aberrantly Binding miRNAs{"} (ABMs) that can bind to the target NHR genes. In this study, for human miR-548, rat miR-Let-7 and miR-30, mouse miR-466 are identified as potential ABMs families. We also found the list of genes targeting ABMs. Specifically, these miRNAs majorly targeted to bind nuclear subfamily receptor genes in all studied animal species. ABMs family interaction with NHR genes is favored by AT richness and the length of the gene. Our findings suggest that, specific ABMs family targeting NHRs may act as potential candidates to regulate the downstream signaling pathways.",
keywords = "Journal Article",
author = "Jeyalakshmi Kandhavelu and Suresh Palanivel and Meenakshisundaram Kandhavelu",
note = "Copyright{\circledC} Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.",
year = "2017",
month = "7",
day = "24",
doi = "10.2174/2211536606666170724155252",
language = "English",
journal = "MicroRNA",
issn = "2211-5374",
publisher = "Bentham Science Publishers",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Aberrantly binding microRNAs and their interactions with nuclear hormone receptors

AU - Kandhavelu, Jeyalakshmi

AU - Palanivel, Suresh

AU - Kandhavelu, Meenakshisundaram

N1 - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

PY - 2017/7/24

Y1 - 2017/7/24

N2 - Nuclear Hormone Receptors (NHRs) are the most important targets that plays vital role in cellular signaling pathways of disease. Regulation of NHRs by using potential non-coding RNAs, miRNA, is clinically important to control a disease. However, the detailed status of miRNA interactions with NHRs remains unclear. Hence, the focus of present study is to investigate the interface at the genome-wide level in human, mouse and rat using computational biology approach. This big-data analysis explored thousands of available miRNAs interactions with the NHRs and the results showed that 11 miRNAs have conserved targets, where six miRNAs genetically conserved among different species. This implies that both conserved and non-conserved miRNAs have a potential role in NHRs regulation. We found several "Aberrantly Binding miRNAs" (ABMs) that can bind to the target NHR genes. In this study, for human miR-548, rat miR-Let-7 and miR-30, mouse miR-466 are identified as potential ABMs families. We also found the list of genes targeting ABMs. Specifically, these miRNAs majorly targeted to bind nuclear subfamily receptor genes in all studied animal species. ABMs family interaction with NHR genes is favored by AT richness and the length of the gene. Our findings suggest that, specific ABMs family targeting NHRs may act as potential candidates to regulate the downstream signaling pathways.

AB - Nuclear Hormone Receptors (NHRs) are the most important targets that plays vital role in cellular signaling pathways of disease. Regulation of NHRs by using potential non-coding RNAs, miRNA, is clinically important to control a disease. However, the detailed status of miRNA interactions with NHRs remains unclear. Hence, the focus of present study is to investigate the interface at the genome-wide level in human, mouse and rat using computational biology approach. This big-data analysis explored thousands of available miRNAs interactions with the NHRs and the results showed that 11 miRNAs have conserved targets, where six miRNAs genetically conserved among different species. This implies that both conserved and non-conserved miRNAs have a potential role in NHRs regulation. We found several "Aberrantly Binding miRNAs" (ABMs) that can bind to the target NHR genes. In this study, for human miR-548, rat miR-Let-7 and miR-30, mouse miR-466 are identified as potential ABMs families. We also found the list of genes targeting ABMs. Specifically, these miRNAs majorly targeted to bind nuclear subfamily receptor genes in all studied animal species. ABMs family interaction with NHR genes is favored by AT richness and the length of the gene. Our findings suggest that, specific ABMs family targeting NHRs may act as potential candidates to regulate the downstream signaling pathways.

KW - Journal Article

U2 - 10.2174/2211536606666170724155252

DO - 10.2174/2211536606666170724155252

M3 - Article

JO - MicroRNA

JF - MicroRNA

SN - 2211-5374

ER -