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Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease

Tutkimustuotosvertaisarvioitu

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Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease. / Cheng, Sulin; Wiklund, Petri; Autio, Reija; Borra, Ronald; Ojanen, Xiaowei; Xu, Leiting; Törmäkangas, Timo; Alen, Markku.

julkaisussa: PLoS ONE, Vuosikerta 10, Nro 10, 0138889, 06.10.2015.

Tutkimustuotosvertaisarvioitu

Harvard

Cheng, S, Wiklund, P, Autio, R, Borra, R, Ojanen, X, Xu, L, Törmäkangas, T & Alen, M 2015, 'Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease', PLoS ONE, Vuosikerta. 10, Nro 10, 0138889. https://doi.org/10.1371/journal.pone.0138889

APA

Cheng, S., Wiklund, P., Autio, R., Borra, R., Ojanen, X., Xu, L., ... Alen, M. (2015). Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease. PLoS ONE, 10(10), [0138889]. https://doi.org/10.1371/journal.pone.0138889

Vancouver

Author

Cheng, Sulin ; Wiklund, Petri ; Autio, Reija ; Borra, Ronald ; Ojanen, Xiaowei ; Xu, Leiting ; Törmäkangas, Timo ; Alen, Markku. / Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease. Julkaisussa: PLoS ONE. 2015 ; Vuosikerta 10, Nro 10.

Bibtex - Lataa

@article{a75d60a340cc454d9f27508d935915b2,
title = "Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease",
abstract = "BackgroundFatty liver is a major cause of obesity-related morbidity and mortality. The aim of this study was to identify early metabolic alterations associated with liver fat accumulation in 50- to 55-year-old men (n = 49) and women (n = 52) with and without NAFLD.MethodsHepatic fat content was measured using proton magnetic resonance spectroscopy (H-1 MRS). Serum samples were analyzed using a nuclear magnetic resonance (NMR) metabolomics platform. Global gene expression profiles of adipose tissues and skeletal muscle were analyzed using Affymetrix microarrays and quantitative PCR. Muscle protein expression was analyzed by Western blot.ResultsIncreased branched-chain amino acid (BCAA), aromatic amino acid (AAA) and orosomucoid were associated with liver fat accumulation already in its early stage, independent of sex, obesity or insulin resistance (pConclusionsLiver fat accumulation, already in its early stage, is associated with increased serum branched-chain and aromatic amino acids. The observed associations of decreased BCAA catabolism activity, mitochondrial energy metabolism and serum BCAA concentration with liver fat content suggest that adipose tissue dysfunction may have a key role in the systemic nature of NAFLD pathogenesis.",
keywords = "MUSCLE INSULIN-RESISTANCE, HEPATIC STEATOSIS, SKELETAL-MUSCLE, MAGNETIC-RESONANCE, BODY-COMPOSITION, OBESITY, WOMEN, GIRLS, INFLAMMATION, PATHOGENESIS",
author = "Sulin Cheng and Petri Wiklund and Reija Autio and Ronald Borra and Xiaowei Ojanen and Leiting Xu and Timo T{\"o}rm{\"a}kangas and Markku Alen",
year = "2015",
month = "10",
day = "6",
doi = "10.1371/journal.pone.0138889",
language = "English",
volume = "10",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease

AU - Cheng, Sulin

AU - Wiklund, Petri

AU - Autio, Reija

AU - Borra, Ronald

AU - Ojanen, Xiaowei

AU - Xu, Leiting

AU - Törmäkangas, Timo

AU - Alen, Markku

PY - 2015/10/6

Y1 - 2015/10/6

N2 - BackgroundFatty liver is a major cause of obesity-related morbidity and mortality. The aim of this study was to identify early metabolic alterations associated with liver fat accumulation in 50- to 55-year-old men (n = 49) and women (n = 52) with and without NAFLD.MethodsHepatic fat content was measured using proton magnetic resonance spectroscopy (H-1 MRS). Serum samples were analyzed using a nuclear magnetic resonance (NMR) metabolomics platform. Global gene expression profiles of adipose tissues and skeletal muscle were analyzed using Affymetrix microarrays and quantitative PCR. Muscle protein expression was analyzed by Western blot.ResultsIncreased branched-chain amino acid (BCAA), aromatic amino acid (AAA) and orosomucoid were associated with liver fat accumulation already in its early stage, independent of sex, obesity or insulin resistance (pConclusionsLiver fat accumulation, already in its early stage, is associated with increased serum branched-chain and aromatic amino acids. The observed associations of decreased BCAA catabolism activity, mitochondrial energy metabolism and serum BCAA concentration with liver fat content suggest that adipose tissue dysfunction may have a key role in the systemic nature of NAFLD pathogenesis.

AB - BackgroundFatty liver is a major cause of obesity-related morbidity and mortality. The aim of this study was to identify early metabolic alterations associated with liver fat accumulation in 50- to 55-year-old men (n = 49) and women (n = 52) with and without NAFLD.MethodsHepatic fat content was measured using proton magnetic resonance spectroscopy (H-1 MRS). Serum samples were analyzed using a nuclear magnetic resonance (NMR) metabolomics platform. Global gene expression profiles of adipose tissues and skeletal muscle were analyzed using Affymetrix microarrays and quantitative PCR. Muscle protein expression was analyzed by Western blot.ResultsIncreased branched-chain amino acid (BCAA), aromatic amino acid (AAA) and orosomucoid were associated with liver fat accumulation already in its early stage, independent of sex, obesity or insulin resistance (pConclusionsLiver fat accumulation, already in its early stage, is associated with increased serum branched-chain and aromatic amino acids. The observed associations of decreased BCAA catabolism activity, mitochondrial energy metabolism and serum BCAA concentration with liver fat content suggest that adipose tissue dysfunction may have a key role in the systemic nature of NAFLD pathogenesis.

KW - MUSCLE INSULIN-RESISTANCE

KW - HEPATIC STEATOSIS

KW - SKELETAL-MUSCLE

KW - MAGNETIC-RESONANCE

KW - BODY-COMPOSITION

KW - OBESITY

KW - WOMEN

KW - GIRLS

KW - INFLAMMATION

KW - PATHOGENESIS

U2 - 10.1371/journal.pone.0138889

DO - 10.1371/journal.pone.0138889

M3 - Article

VL - 10

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 10

M1 - 0138889

ER -