TUTCRIS - Tampereen teknillinen yliopisto

TUTCRIS

AROS has a context-dependent effect on SIRT1

Tutkimustuotosvertaisarvioitu

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut1523-1528
Sivumäärä6
JulkaisuFEBS Letters
Vuosikerta588
Numero9
DOI - pysyväislinkit
TilaJulkaistu - 2 toukokuuta 2014
OKM-julkaisutyyppiA1 Alkuperäisartikkeli

Tiivistelmä

The modulation of protein deacetylase SIRT1 has a vast therapeutic potential in treatment of several aging-associated diseases. Active regulator of SIRT1 (AROS) is a small endogenous protein which was originally reported to activate SIRT1 through a direct interaction in cancer cells. We show that the interaction between the two proteins is weak and does not alter the activity of SIRT1 in non-cancerous human cells. The results of different in vitro SIRT1 activity assays disclosed AROS as an inhibitor of SIRT1. The functional relationship between AROS and SIRT1 proved to be dependent on the biological context and experimental setting.