TUTCRIS - Tampereen teknillinen yliopisto

TUTCRIS

Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events

Tutkimustuotosvertaisarvioitu

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut214-217
Sivumäärä4
JulkaisuAtherosclerosis
Vuosikerta234
Numero1
DOI - pysyväislinkit
TilaJulkaistu - 2014
OKM-julkaisutyyppiA1 Alkuperäisartikkeli

Tiivistelmä

Background and purpose: Patients with genetic background for high circulating oxidized low-density lipoprotein (oxLDL) levels might be at an increased risk of cerebrovascular disease (CVD). Methods: The association of oxLDL-variant rs676210 with CVD events was studied in patients undergoing coronary angiography (study A; N=2913 [271 cases]). We sought to replicate the results in a large genome-wide association study meta-analysis of ischaemic stroke (study B; N=3548 cases, 5972 controls). Results: In study A, the prevalence of hypertension, diabetes and >50% carotid stenosis as well as the levels of LDL cholesterol differed significantly between cases and controls. In a logistic regression model adjusted for the significant covariates, rs676210 associated with CVD events (p=0.030; odds ratio=1.29 [95% confidence interval 1.03-1.63] for risk allele G). In study B, rs676210 did not associate with the history of ischaemic stroke. Conclusions: The oxLDL levels increasing variant rs676210 associates with CVD events in patients undergoing coronary angiography.

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