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Bioimpedance Sensor Array for Long-Term Monitoring of Wound Healing from Beneath the Primary Dressings and Controlled Formation of H2O2 Using Low-Intensity Direct Current

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Bioimpedance Sensor Array for Long-Term Monitoring of Wound Healing from Beneath the Primary Dressings and Controlled Formation of H2O2 Using Low-Intensity Direct Current. / Kekonen, Atte; Bergelin, Mikael; Johansson, Max; Kumar Joon, Narender; Bobacka, Johan; Viik, Jari.

julkaisussa: Sensors, Vuosikerta 19, Nro 11, 31.05.2019.

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Kekonen, Atte ; Bergelin, Mikael ; Johansson, Max ; Kumar Joon, Narender ; Bobacka, Johan ; Viik, Jari. / Bioimpedance Sensor Array for Long-Term Monitoring of Wound Healing from Beneath the Primary Dressings and Controlled Formation of H2O2 Using Low-Intensity Direct Current. Julkaisussa: Sensors. 2019 ; Vuosikerta 19, Nro 11.

Bibtex - Lataa

@article{5a0559a9dc96481cb5aa88dc98180bc4,
title = "Bioimpedance Sensor Array for Long-Term Monitoring of Wound Healing from Beneath the Primary Dressings and Controlled Formation of H2O2 Using Low-Intensity Direct Current",
abstract = "Chronic wounds impose a significant financial burden for the healthcare system. Currently, assessment and monitoring of hard-to-heal wounds are often based on visual means and measuring the size of the wound. The primary wound dressings must be removed before assessment can be done. We have developed a quasi-monopolar bioimpedance-measurement-based method and a measurement system to determine the status of wound healing. The objective of this study was to demonstrate that with an appropriate setup, long-term monitoring of wound healing from beneath the primary dressings is feasible. The developed multielectrode sensor array was applied on the wound area and left under the primary dressings for 142 h. The impedance of the wounds and the surrounding intact skin area was measured regularly during the study at 150 Hz, 300 Hz, 1 kHz, and 5 kHz frequencies. At the end of the follow-up period, the wound impedance had reached the impedance of the intact skin at the higher frequencies and increased significantly at the lowest frequencies. The measurement frequency affected the measurement sensitivity in wound monitoring. The skin impedance remained stable over the measurement period. The sensor array also enabled the administration of periodical low-intensity direct current (LIDC) stimulation in order to create an antimicrobial environment across the wound area via the controlled formation of hydrogen peroxide (H2O2).",
keywords = "beneath the dressings, bioimpedance, hydrogen peroxide, long-term monitoring, low-intensity direct current, multielectrode, quasi-monopolar, sensor array, wound dressing, wound monitoring, wound stimulation",
author = "Atte Kekonen and Mikael Bergelin and Max Johansson and {Kumar Joon}, Narender and Johan Bobacka and Jari Viik",
year = "2019",
month = "5",
day = "31",
doi = "10.3390/s19112505",
language = "English",
volume = "19",
journal = "Sensors",
issn = "1424-8220",
publisher = "MDPI",
number = "11",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Bioimpedance Sensor Array for Long-Term Monitoring of Wound Healing from Beneath the Primary Dressings and Controlled Formation of H2O2 Using Low-Intensity Direct Current

AU - Kekonen, Atte

AU - Bergelin, Mikael

AU - Johansson, Max

AU - Kumar Joon, Narender

AU - Bobacka, Johan

AU - Viik, Jari

PY - 2019/5/31

Y1 - 2019/5/31

N2 - Chronic wounds impose a significant financial burden for the healthcare system. Currently, assessment and monitoring of hard-to-heal wounds are often based on visual means and measuring the size of the wound. The primary wound dressings must be removed before assessment can be done. We have developed a quasi-monopolar bioimpedance-measurement-based method and a measurement system to determine the status of wound healing. The objective of this study was to demonstrate that with an appropriate setup, long-term monitoring of wound healing from beneath the primary dressings is feasible. The developed multielectrode sensor array was applied on the wound area and left under the primary dressings for 142 h. The impedance of the wounds and the surrounding intact skin area was measured regularly during the study at 150 Hz, 300 Hz, 1 kHz, and 5 kHz frequencies. At the end of the follow-up period, the wound impedance had reached the impedance of the intact skin at the higher frequencies and increased significantly at the lowest frequencies. The measurement frequency affected the measurement sensitivity in wound monitoring. The skin impedance remained stable over the measurement period. The sensor array also enabled the administration of periodical low-intensity direct current (LIDC) stimulation in order to create an antimicrobial environment across the wound area via the controlled formation of hydrogen peroxide (H2O2).

AB - Chronic wounds impose a significant financial burden for the healthcare system. Currently, assessment and monitoring of hard-to-heal wounds are often based on visual means and measuring the size of the wound. The primary wound dressings must be removed before assessment can be done. We have developed a quasi-monopolar bioimpedance-measurement-based method and a measurement system to determine the status of wound healing. The objective of this study was to demonstrate that with an appropriate setup, long-term monitoring of wound healing from beneath the primary dressings is feasible. The developed multielectrode sensor array was applied on the wound area and left under the primary dressings for 142 h. The impedance of the wounds and the surrounding intact skin area was measured regularly during the study at 150 Hz, 300 Hz, 1 kHz, and 5 kHz frequencies. At the end of the follow-up period, the wound impedance had reached the impedance of the intact skin at the higher frequencies and increased significantly at the lowest frequencies. The measurement frequency affected the measurement sensitivity in wound monitoring. The skin impedance remained stable over the measurement period. The sensor array also enabled the administration of periodical low-intensity direct current (LIDC) stimulation in order to create an antimicrobial environment across the wound area via the controlled formation of hydrogen peroxide (H2O2).

KW - beneath the dressings

KW - bioimpedance

KW - hydrogen peroxide

KW - long-term monitoring

KW - low-intensity direct current

KW - multielectrode

KW - quasi-monopolar

KW - sensor array

KW - wound dressing

KW - wound monitoring

KW - wound stimulation

U2 - 10.3390/s19112505

DO - 10.3390/s19112505

M3 - Article

VL - 19

JO - Sensors

JF - Sensors

SN - 1424-8220

IS - 11

ER -