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Changes in hemodynamics associated with metabolic syndrome are more pronounced in women than in men

Tutkimustuotosvertaisarvioitu

Standard

Changes in hemodynamics associated with metabolic syndrome are more pronounced in women than in men. / Kangas, Pauliina; Tikkakoski, Antti; Kettunen, Jarkko; Eräranta, Arttu; Huhtala, Heini; Kähönen, Mika; Sipilä, Kalle; Mustonen, Jukka; Pörsti, Ilkka.

julkaisussa: Scientific Reports, Vuosikerta 9, Nro 1, 18377, 05.12.2019.

Tutkimustuotosvertaisarvioitu

Harvard

Kangas, P, Tikkakoski, A, Kettunen, J, Eräranta, A, Huhtala, H, Kähönen, M, Sipilä, K, Mustonen, J & Pörsti, I 2019, 'Changes in hemodynamics associated with metabolic syndrome are more pronounced in women than in men', Scientific Reports, Vuosikerta. 9, Nro 1, 18377. https://doi.org/10.1038/s41598-019-54926-0

APA

Kangas, P., Tikkakoski, A., Kettunen, J., Eräranta, A., Huhtala, H., Kähönen, M., ... Pörsti, I. (2019). Changes in hemodynamics associated with metabolic syndrome are more pronounced in women than in men. Scientific Reports, 9(1), [18377]. https://doi.org/10.1038/s41598-019-54926-0

Vancouver

Kangas P, Tikkakoski A, Kettunen J, Eräranta A, Huhtala H, Kähönen M et al. Changes in hemodynamics associated with metabolic syndrome are more pronounced in women than in men. Scientific Reports. 2019 joulu 5;9(1). 18377. https://doi.org/10.1038/s41598-019-54926-0

Author

Kangas, Pauliina ; Tikkakoski, Antti ; Kettunen, Jarkko ; Eräranta, Arttu ; Huhtala, Heini ; Kähönen, Mika ; Sipilä, Kalle ; Mustonen, Jukka ; Pörsti, Ilkka. / Changes in hemodynamics associated with metabolic syndrome are more pronounced in women than in men. Julkaisussa: Scientific Reports. 2019 ; Vuosikerta 9, Nro 1.

Bibtex - Lataa

@article{1613aad009ef43a0bc3314fcb0c18466,
title = "Changes in hemodynamics associated with metabolic syndrome are more pronounced in women than in men",
abstract = "The increase in cardiovascular risk associated with metabolic syndrome (MS) seems higher in women than in men. We examined hemodynamics during head-up tilt in 252 men and 250 women without atherosclerosis, diabetes, or antihypertensive medication, mean age 48 years, using whole-body impedance cardiography and radial pulse wave analysis. MS was defined according to Alberti et al. 2009. Men and women with MS presented with corresponding elevations of systolic and diastolic blood pressure (10-14{\%}, p ≤ 0.001) versus controls. Supine pulse wave velocity (16–17{\%}, p < 0.001) and systemic vascular resistance (7–9{\%}, p ≤ 0.026), and upright cardiac output (6–11{\%}, p ≤ 0.008) were higher in both MS groups than controls. Elevation of supine aortic characteristic impedance was higher in women than in men with MS (16{\%} vs. 8{\%}, p = 0.026), and in contrast to men, no upright impedance reduction was observed in women. When upright, women but not men with MS showed faster return of reflected pressure wave (p = 0.036), and smaller decrease in left cardiac work (p = 0.035) versus controls. The faster upright return of reflected pressure, lower upright decrease in left cardiac work, and higher elevation of aortic characteristic impedance may contribute to the greater increase in MS-related cardiovascular risk in women than in men.",
author = "Pauliina Kangas and Antti Tikkakoski and Jarkko Kettunen and Arttu Er{\"a}ranta and Heini Huhtala and Mika K{\"a}h{\"o}nen and Kalle Sipil{\"a} and Jukka Mustonen and Ilkka P{\"o}rsti",
year = "2019",
month = "12",
day = "5",
doi = "10.1038/s41598-019-54926-0",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Changes in hemodynamics associated with metabolic syndrome are more pronounced in women than in men

AU - Kangas, Pauliina

AU - Tikkakoski, Antti

AU - Kettunen, Jarkko

AU - Eräranta, Arttu

AU - Huhtala, Heini

AU - Kähönen, Mika

AU - Sipilä, Kalle

AU - Mustonen, Jukka

AU - Pörsti, Ilkka

PY - 2019/12/5

Y1 - 2019/12/5

N2 - The increase in cardiovascular risk associated with metabolic syndrome (MS) seems higher in women than in men. We examined hemodynamics during head-up tilt in 252 men and 250 women without atherosclerosis, diabetes, or antihypertensive medication, mean age 48 years, using whole-body impedance cardiography and radial pulse wave analysis. MS was defined according to Alberti et al. 2009. Men and women with MS presented with corresponding elevations of systolic and diastolic blood pressure (10-14%, p ≤ 0.001) versus controls. Supine pulse wave velocity (16–17%, p < 0.001) and systemic vascular resistance (7–9%, p ≤ 0.026), and upright cardiac output (6–11%, p ≤ 0.008) were higher in both MS groups than controls. Elevation of supine aortic characteristic impedance was higher in women than in men with MS (16% vs. 8%, p = 0.026), and in contrast to men, no upright impedance reduction was observed in women. When upright, women but not men with MS showed faster return of reflected pressure wave (p = 0.036), and smaller decrease in left cardiac work (p = 0.035) versus controls. The faster upright return of reflected pressure, lower upright decrease in left cardiac work, and higher elevation of aortic characteristic impedance may contribute to the greater increase in MS-related cardiovascular risk in women than in men.

AB - The increase in cardiovascular risk associated with metabolic syndrome (MS) seems higher in women than in men. We examined hemodynamics during head-up tilt in 252 men and 250 women without atherosclerosis, diabetes, or antihypertensive medication, mean age 48 years, using whole-body impedance cardiography and radial pulse wave analysis. MS was defined according to Alberti et al. 2009. Men and women with MS presented with corresponding elevations of systolic and diastolic blood pressure (10-14%, p ≤ 0.001) versus controls. Supine pulse wave velocity (16–17%, p < 0.001) and systemic vascular resistance (7–9%, p ≤ 0.026), and upright cardiac output (6–11%, p ≤ 0.008) were higher in both MS groups than controls. Elevation of supine aortic characteristic impedance was higher in women than in men with MS (16% vs. 8%, p = 0.026), and in contrast to men, no upright impedance reduction was observed in women. When upright, women but not men with MS showed faster return of reflected pressure wave (p = 0.036), and smaller decrease in left cardiac work (p = 0.035) versus controls. The faster upright return of reflected pressure, lower upright decrease in left cardiac work, and higher elevation of aortic characteristic impedance may contribute to the greater increase in MS-related cardiovascular risk in women than in men.

U2 - 10.1038/s41598-019-54926-0

DO - 10.1038/s41598-019-54926-0

M3 - Article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 18377

ER -