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Cholesterol oxidation products and their biological importance

Tutkimustuotosvertaisarvioitu

Standard

Cholesterol oxidation products and their biological importance. / Kulig, Waldemar; Cwiklik, Lukasz; Jurkiewicz, Piotr; Rog, Tomasz; Vattulainen, Ilpo.

julkaisussa: Chemistry and Physics of Lipids, Vuosikerta 199, 2016, s. 144-160.

Tutkimustuotosvertaisarvioitu

Harvard

Kulig, W, Cwiklik, L, Jurkiewicz, P, Rog, T & Vattulainen, I 2016, 'Cholesterol oxidation products and their biological importance', Chemistry and Physics of Lipids, Vuosikerta. 199, Sivut 144-160. https://doi.org/10.1016/j.chemphyslip.2016.03.001

APA

Kulig, W., Cwiklik, L., Jurkiewicz, P., Rog, T., & Vattulainen, I. (2016). Cholesterol oxidation products and their biological importance. Chemistry and Physics of Lipids, 199, 144-160. https://doi.org/10.1016/j.chemphyslip.2016.03.001

Vancouver

Kulig W, Cwiklik L, Jurkiewicz P, Rog T, Vattulainen I. Cholesterol oxidation products and their biological importance. Chemistry and Physics of Lipids. 2016;199:144-160. https://doi.org/10.1016/j.chemphyslip.2016.03.001

Author

Kulig, Waldemar ; Cwiklik, Lukasz ; Jurkiewicz, Piotr ; Rog, Tomasz ; Vattulainen, Ilpo. / Cholesterol oxidation products and their biological importance. Julkaisussa: Chemistry and Physics of Lipids. 2016 ; Vuosikerta 199. Sivut 144-160.

Bibtex - Lataa

@article{0d489b9e12ef4971b389d6441f9ac0ef,
title = "Cholesterol oxidation products and their biological importance",
abstract = "The main biological cause of oxysterols is the oxidation of cholesterol. They differ from cholesterol by the presence of additional polar groups that are typically hydroxyl, keto, hydroperoxy, epoxy, or carboxyl moieties. Under typical conditions, oxysterol concentration is maintained at a very low and precisely regulated level, with an excess of cholesterol. Like cholesterol, many oxysterols are hydrophobic and hence confined to cell membranes. However, small chemical differences between the sterols can significantly affect how they interact with other membrane components, and this in turn can have a substantial effect on membrane properties. In this spirit, this review describes the biological importance and the roles of oxysterols in the human body. We focus primarily on the effect of oxysterols on lipid membranes, but we also consider other issues such as enzymatic and nonenzymatic synthesis processes of oxysterols as well as pathological conditions induced by oxysterols.",
keywords = "Biological membranes, Biophysical properties, Cholesterol, Oxidation, Oxidative stress, Oxysterols, Reactive oxygen species",
author = "Waldemar Kulig and Lukasz Cwiklik and Piotr Jurkiewicz and Tomasz Rog and Ilpo Vattulainen",
note = "EXT={"}Cwiklik, Lukasz{"}",
year = "2016",
doi = "10.1016/j.chemphyslip.2016.03.001",
language = "English",
volume = "199",
pages = "144--160",
journal = "Chemistry and Physics of Lipids",
issn = "0009-3084",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Cholesterol oxidation products and their biological importance

AU - Kulig, Waldemar

AU - Cwiklik, Lukasz

AU - Jurkiewicz, Piotr

AU - Rog, Tomasz

AU - Vattulainen, Ilpo

N1 - EXT="Cwiklik, Lukasz"

PY - 2016

Y1 - 2016

N2 - The main biological cause of oxysterols is the oxidation of cholesterol. They differ from cholesterol by the presence of additional polar groups that are typically hydroxyl, keto, hydroperoxy, epoxy, or carboxyl moieties. Under typical conditions, oxysterol concentration is maintained at a very low and precisely regulated level, with an excess of cholesterol. Like cholesterol, many oxysterols are hydrophobic and hence confined to cell membranes. However, small chemical differences between the sterols can significantly affect how they interact with other membrane components, and this in turn can have a substantial effect on membrane properties. In this spirit, this review describes the biological importance and the roles of oxysterols in the human body. We focus primarily on the effect of oxysterols on lipid membranes, but we also consider other issues such as enzymatic and nonenzymatic synthesis processes of oxysterols as well as pathological conditions induced by oxysterols.

AB - The main biological cause of oxysterols is the oxidation of cholesterol. They differ from cholesterol by the presence of additional polar groups that are typically hydroxyl, keto, hydroperoxy, epoxy, or carboxyl moieties. Under typical conditions, oxysterol concentration is maintained at a very low and precisely regulated level, with an excess of cholesterol. Like cholesterol, many oxysterols are hydrophobic and hence confined to cell membranes. However, small chemical differences between the sterols can significantly affect how they interact with other membrane components, and this in turn can have a substantial effect on membrane properties. In this spirit, this review describes the biological importance and the roles of oxysterols in the human body. We focus primarily on the effect of oxysterols on lipid membranes, but we also consider other issues such as enzymatic and nonenzymatic synthesis processes of oxysterols as well as pathological conditions induced by oxysterols.

KW - Biological membranes

KW - Biophysical properties

KW - Cholesterol

KW - Oxidation

KW - Oxidative stress

KW - Oxysterols

KW - Reactive oxygen species

U2 - 10.1016/j.chemphyslip.2016.03.001

DO - 10.1016/j.chemphyslip.2016.03.001

M3 - Article

VL - 199

SP - 144

EP - 160

JO - Chemistry and Physics of Lipids

JF - Chemistry and Physics of Lipids

SN - 0009-3084

ER -