Computational modeling of neuron-astrocyte interactions: Evolution, reproducibility, comparability and future development of models
Tutkimustuotos › › vertaisarvioitu
|DOI - pysyväislinkit|
|Tila||Julkaistu - 2018|
|Tapahtuma||27th Annual Computational Neuroscience Meeting (CNS*2018) - Seattle, Yhdysvallat|
Kesto: 13 heinäkuuta 2018 → 18 heinäkuuta 2018
Astrocyte research has turned out to be a fascinating and popular research field with two groups of researchers having opposite opinions about the importance of astrocytes in brain information processing and plasticity [1–3]. We believe that computational modeling of the biophysics of neuron-astrocyte interactions can greatly help address the dilemma.We have therefore, as the first ones, characterized, categorized, and evaluated in detail more than a hundred published computational models of single astrocytes, astrocyte networks, neuron-astrocyte synapses, and neuron-astrocyte networks  as well as studied the reproducibility and comparability of some of the models . Based on this knowledge and additional experimental findings, we have constructed and implemented new neuron-astrocyte synapse models . In this study, we propose to gather the state-of-the-art experimental and computational knowledge to help guide the future astrocyte research. Two of the most important challenges in experimental work on astrocytes are the lack of selective pharmacological tools and the partially contradictory results obtained in in vivo and in vitro studies [1–3]. In computational studies on astrocyte, the most important challenges are the creationof new models without clear explanation how they differ from the previously published models and what new predictions the models make . Furthermore, combining unclearly given model details in the publications with nonexistent online model implementations make the reproducibility and comparability studies as well as the development of previously published models impossible, or at least difficult [4, 5]. We want to emphasize the importance of using common description formats for defining the models in the publications and description languages for exchanging the models through online repositories. Our overall goal is to develop both detailed and reduced models of neuron-astrocyte interactions for different brain areas, allowing additional testing and clarification of the controversies observed in experimental wet-lab studies [1–3]. Only through systematic integration of in vivo, in vitro, and in silicodata, using reproducible science approach, are we be able to understand how astrocytes may contribute to brain information processing and plasticity.
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