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Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome

Tutkimustuotosvertaisarvioitu

Standard

Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome. / Paananen, Riku O.; Javanainen, Matti; Holopainen, Juha M.; Vattulainen, Ilpo.

julkaisussa: Journal of Physical Chemistry Letters, Vuosikerta 10, Nro 14, 25.06.2019, s. 3893-3898.

Tutkimustuotosvertaisarvioitu

Harvard

Paananen, RO, Javanainen, M, Holopainen, JM & Vattulainen, I 2019, 'Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome', Journal of Physical Chemistry Letters, Vuosikerta. 10, Nro 14, Sivut 3893-3898. https://doi.org/10.1021/acs.jpclett.9b01187

APA

Paananen, R. O., Javanainen, M., Holopainen, J. M., & Vattulainen, I. (2019). Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome. Journal of Physical Chemistry Letters, 10(14), 3893-3898. https://doi.org/10.1021/acs.jpclett.9b01187

Vancouver

Paananen RO, Javanainen M, Holopainen JM, Vattulainen I. Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome. Journal of Physical Chemistry Letters. 2019 kesä 25;10(14):3893-3898. https://doi.org/10.1021/acs.jpclett.9b01187

Author

Paananen, Riku O. ; Javanainen, Matti ; Holopainen, Juha M. ; Vattulainen, Ilpo. / Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome. Julkaisussa: Journal of Physical Chemistry Letters. 2019 ; Vuosikerta 10, Nro 14. Sivut 3893-3898.

Bibtex - Lataa

@article{d41bbe08bf8449919d7b8627193cacd9,
title = "Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome",
abstract = "Dry eye syndrome (DES), one of the most common ophthalmological diseases, is typically caused by excessive evaporation of tear fluid from the ocular surface. Excessive evaporation is linked to impaired function of the tear film lipid layer (TFLL) that covers the aqueous tear film. The principles of the evaporation resistance of the TFLL have remained unknown, however. We combined atomistic simulations with Brewster angle microscopy and surface potential experiments to explore the organization and evaporation resistance of films composed of wax esters, one of the main components of the TFLL. The results provide evidence that the evaporation resistance of the TFLL is based on crystalline-state layers of wax esters and that the evaporation rate is determined by defects in the TFLL and its coverage on the ocular surface. On the basis of the results, uncovering the nonequilibrium spreading and crystallization of TFLL films has potential to reveal new means of treating DES.",
author = "Paananen, {Riku O.} and Matti Javanainen and Holopainen, {Juha M.} and Ilpo Vattulainen",
note = "EXT={"}Paananen, Riku O.{"}",
year = "2019",
month = "6",
day = "25",
doi = "10.1021/acs.jpclett.9b01187",
language = "English",
volume = "10",
pages = "3893--3898",
journal = "Journal of Physical Chemistry Letters",
issn = "1948-7185",
publisher = "American Chemical Society",
number = "14",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome

AU - Paananen, Riku O.

AU - Javanainen, Matti

AU - Holopainen, Juha M.

AU - Vattulainen, Ilpo

N1 - EXT="Paananen, Riku O."

PY - 2019/6/25

Y1 - 2019/6/25

N2 - Dry eye syndrome (DES), one of the most common ophthalmological diseases, is typically caused by excessive evaporation of tear fluid from the ocular surface. Excessive evaporation is linked to impaired function of the tear film lipid layer (TFLL) that covers the aqueous tear film. The principles of the evaporation resistance of the TFLL have remained unknown, however. We combined atomistic simulations with Brewster angle microscopy and surface potential experiments to explore the organization and evaporation resistance of films composed of wax esters, one of the main components of the TFLL. The results provide evidence that the evaporation resistance of the TFLL is based on crystalline-state layers of wax esters and that the evaporation rate is determined by defects in the TFLL and its coverage on the ocular surface. On the basis of the results, uncovering the nonequilibrium spreading and crystallization of TFLL films has potential to reveal new means of treating DES.

AB - Dry eye syndrome (DES), one of the most common ophthalmological diseases, is typically caused by excessive evaporation of tear fluid from the ocular surface. Excessive evaporation is linked to impaired function of the tear film lipid layer (TFLL) that covers the aqueous tear film. The principles of the evaporation resistance of the TFLL have remained unknown, however. We combined atomistic simulations with Brewster angle microscopy and surface potential experiments to explore the organization and evaporation resistance of films composed of wax esters, one of the main components of the TFLL. The results provide evidence that the evaporation resistance of the TFLL is based on crystalline-state layers of wax esters and that the evaporation rate is determined by defects in the TFLL and its coverage on the ocular surface. On the basis of the results, uncovering the nonequilibrium spreading and crystallization of TFLL films has potential to reveal new means of treating DES.

U2 - 10.1021/acs.jpclett.9b01187

DO - 10.1021/acs.jpclett.9b01187

M3 - Article

VL - 10

SP - 3893

EP - 3898

JO - Journal of Physical Chemistry Letters

JF - Journal of Physical Chemistry Letters

SN - 1948-7185

IS - 14

ER -