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Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD

Tutkimustuotosvertaisarvioitu

Standard

Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD. / Lehti, Maarit; Valkeinen, Heli; Sipilä, Sarianna; Perhonen, Merja; Rottensteiner, Mirva; Pullinen, Teemu; Pietiläinen, Rauno; Nyman, Kai; Vehkaoja, Antti; Kainulainen, Heikki; Kujala, Urho M.

julkaisussa: American Journal of Translational Research, Vuosikerta 12, Nro 8, 2020, s. 4582-4593.

Tutkimustuotosvertaisarvioitu

Harvard

Lehti, M, Valkeinen, H, Sipilä, S, Perhonen, M, Rottensteiner, M, Pullinen, T, Pietiläinen, R, Nyman, K, Vehkaoja, A, Kainulainen, H & Kujala, UM 2020, 'Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD', American Journal of Translational Research, Vuosikerta. 12, Nro 8, Sivut 4582-4593.

APA

Lehti, M., Valkeinen, H., Sipilä, S., Perhonen, M., Rottensteiner, M., Pullinen, T., ... Kujala, U. M. (2020). Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD. American Journal of Translational Research, 12(8), 4582-4593.

Vancouver

Lehti M, Valkeinen H, Sipilä S, Perhonen M, Rottensteiner M, Pullinen T et al. Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD. American Journal of Translational Research. 2020;12(8):4582-4593.

Author

Lehti, Maarit ; Valkeinen, Heli ; Sipilä, Sarianna ; Perhonen, Merja ; Rottensteiner, Mirva ; Pullinen, Teemu ; Pietiläinen, Rauno ; Nyman, Kai ; Vehkaoja, Antti ; Kainulainen, Heikki ; Kujala, Urho M. / Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD. Julkaisussa: American Journal of Translational Research. 2020 ; Vuosikerta 12, Nro 8. Sivut 4582-4593.

Bibtex - Lataa

@article{97aa1ee943fc4243b6e073fed3e4ca71,
title = "Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD",
abstract = "This study examined the effectiveness, suitability, and safety of a mixed interval-type aerobic and strength training program (MIAST) on physical fitness in patients with stable coronary artery disease (CAD) without history of myocardial infarction (MI). Twenty-three patients with stable CAD were randomly assigned to a MIAST (n = 12; mean age 58.6 years) or control (n = 11; 63.3 years) group. The MIAST group participated in the progressive training program twice a week for 21 weeks. Peak oxygen uptake (VO2peak), workload, and exercise time were measured as were maximal muscle strength, serum lipids, glucose concentration, and the cross-sectional area (CSA) of knee extensors. The safety and suitability of the program were assessed by wireless electrocardiogram (ECG) monitoring and exercise diaries. VO2peak (6.9{\%}; P < 0.05) and exercise time (11.2{\%}; P < 0.05) improved significantly after 12 weeks of training in the MIAST group compared to the control group. Muscle strength (19.9{\%}; P < 0.05) and CSA (2.2{\%}; P < 0.05) increased, and serum lipids and blood glucose tended to decrease after the training. The successful training program (increase in maximal oxygen uptake) increased the gene expression of oxygen metabolism and decreased the gene expression of inflammation pathways in lymphomonocytes. The MIAST program, including interval-type aerobic and strength training, was safe, did not cause any adverse effects, and led to significant improvements in physical fitness in patients with stable CAD.",
keywords = "Coronary heart disease, Endurance training, Oxygen consumption, Physical fitness, Resistance training",
author = "Maarit Lehti and Heli Valkeinen and Sarianna Sipil{\"a} and Merja Perhonen and Mirva Rottensteiner and Teemu Pullinen and Rauno Pietil{\"a}inen and Kai Nyman and Antti Vehkaoja and Heikki Kainulainen and Kujala, {Urho M.}",
year = "2020",
language = "English",
volume = "12",
pages = "4582--4593",
journal = "American Journal of Translational Research",
issn = "1943-8141",
number = "8",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD

AU - Lehti, Maarit

AU - Valkeinen, Heli

AU - Sipilä, Sarianna

AU - Perhonen, Merja

AU - Rottensteiner, Mirva

AU - Pullinen, Teemu

AU - Pietiläinen, Rauno

AU - Nyman, Kai

AU - Vehkaoja, Antti

AU - Kainulainen, Heikki

AU - Kujala, Urho M.

PY - 2020

Y1 - 2020

N2 - This study examined the effectiveness, suitability, and safety of a mixed interval-type aerobic and strength training program (MIAST) on physical fitness in patients with stable coronary artery disease (CAD) without history of myocardial infarction (MI). Twenty-three patients with stable CAD were randomly assigned to a MIAST (n = 12; mean age 58.6 years) or control (n = 11; 63.3 years) group. The MIAST group participated in the progressive training program twice a week for 21 weeks. Peak oxygen uptake (VO2peak), workload, and exercise time were measured as were maximal muscle strength, serum lipids, glucose concentration, and the cross-sectional area (CSA) of knee extensors. The safety and suitability of the program were assessed by wireless electrocardiogram (ECG) monitoring and exercise diaries. VO2peak (6.9%; P < 0.05) and exercise time (11.2%; P < 0.05) improved significantly after 12 weeks of training in the MIAST group compared to the control group. Muscle strength (19.9%; P < 0.05) and CSA (2.2%; P < 0.05) increased, and serum lipids and blood glucose tended to decrease after the training. The successful training program (increase in maximal oxygen uptake) increased the gene expression of oxygen metabolism and decreased the gene expression of inflammation pathways in lymphomonocytes. The MIAST program, including interval-type aerobic and strength training, was safe, did not cause any adverse effects, and led to significant improvements in physical fitness in patients with stable CAD.

AB - This study examined the effectiveness, suitability, and safety of a mixed interval-type aerobic and strength training program (MIAST) on physical fitness in patients with stable coronary artery disease (CAD) without history of myocardial infarction (MI). Twenty-three patients with stable CAD were randomly assigned to a MIAST (n = 12; mean age 58.6 years) or control (n = 11; 63.3 years) group. The MIAST group participated in the progressive training program twice a week for 21 weeks. Peak oxygen uptake (VO2peak), workload, and exercise time were measured as were maximal muscle strength, serum lipids, glucose concentration, and the cross-sectional area (CSA) of knee extensors. The safety and suitability of the program were assessed by wireless electrocardiogram (ECG) monitoring and exercise diaries. VO2peak (6.9%; P < 0.05) and exercise time (11.2%; P < 0.05) improved significantly after 12 weeks of training in the MIAST group compared to the control group. Muscle strength (19.9%; P < 0.05) and CSA (2.2%; P < 0.05) increased, and serum lipids and blood glucose tended to decrease after the training. The successful training program (increase in maximal oxygen uptake) increased the gene expression of oxygen metabolism and decreased the gene expression of inflammation pathways in lymphomonocytes. The MIAST program, including interval-type aerobic and strength training, was safe, did not cause any adverse effects, and led to significant improvements in physical fitness in patients with stable CAD.

KW - Coronary heart disease

KW - Endurance training

KW - Oxygen consumption

KW - Physical fitness

KW - Resistance training

M3 - Article

VL - 12

SP - 4582

EP - 4593

JO - American Journal of Translational Research

JF - American Journal of Translational Research

SN - 1943-8141

IS - 8

ER -