TUTCRIS - Tampereen teknillinen yliopisto

TUTCRIS

Functionalized lipids and surfactants for specific applications

Tutkimustuotosvertaisarvioitu

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut2362-2379
JulkaisuBiochimica et Biophysica Acta: Biomembranes
Vuosikerta1858
Numero10
Varhainen verkossa julkaisun päivämäärä15 tammikuuta 2016
DOI - pysyväislinkit
TilaJulkaistu - lokakuuta 2016
OKM-julkaisutyyppiA1 Alkuperäisartikkeli

Tiivistelmä

Synthetic lipids and surfactants that do not exist in biological systems have been used for the last few decades in both basic and applied science. The most notable applications for synthetic lipids and surfactants are drug delivery, gene transfection, as reporting molecules, and as support for structural lipid biology. In this review, we describe the potential of the synergistic combination of computational and experimental methodologies to study the behavior of synthetic lipids and surfactants embedded in lipid membranes and liposomes. We focused on select cases in which molecular dynamics simulations were used to complement experimental studies aiming to understand the structure and properties of new compounds at the atomistic level. We also describe cases in which molecular dynamics simulations were used to design new synthetic lipids and surfactants, as well as emerging fields for the application of these compounds. This article is part of a Special Issue entitled: Biosimulations edited by Ilpo Vattulainen and Tomasz Róg.

!!ASJC Scopus subject areas

Tutkimusalat

Julkaisufoorumi-taso

Tilastokeskuksen tieteenalat