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Immediate effects of deep brain stimulation of anterior thalamic nuclei on executive functions and emotion-attention interaction in humans

Tutkimustuotosvertaisarvioitu

Standard

Immediate effects of deep brain stimulation of anterior thalamic nuclei on executive functions and emotion-attention interaction in humans. / Hartikainen, Kaisa M.; Sun, Lihua; Polvivaara, Markus; Brause, Maarja; Lehtimäki, Kai; Haapasalo, Joonas; Möttönen, Timo; Väyrynen, Kirsi; Ogawa, Keith H.; Öhman, Juha; Peltola, Jukka.

julkaisussa: JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, Vuosikerta 36, Nro 5, 28.05.2014, s. 540-550.

Tutkimustuotosvertaisarvioitu

Harvard

Hartikainen, KM, Sun, L, Polvivaara, M, Brause, M, Lehtimäki, K, Haapasalo, J, Möttönen, T, Väyrynen, K, Ogawa, KH, Öhman, J & Peltola, J 2014, 'Immediate effects of deep brain stimulation of anterior thalamic nuclei on executive functions and emotion-attention interaction in humans', JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, Vuosikerta. 36, Nro 5, Sivut 540-550. https://doi.org/10.1080/13803395.2014.913554

APA

Hartikainen, K. M., Sun, L., Polvivaara, M., Brause, M., Lehtimäki, K., Haapasalo, J., ... Peltola, J. (2014). Immediate effects of deep brain stimulation of anterior thalamic nuclei on executive functions and emotion-attention interaction in humans. JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 36(5), 540-550. https://doi.org/10.1080/13803395.2014.913554

Vancouver

Hartikainen KM, Sun L, Polvivaara M, Brause M, Lehtimäki K, Haapasalo J et al. Immediate effects of deep brain stimulation of anterior thalamic nuclei on executive functions and emotion-attention interaction in humans. JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY. 2014 touko 28;36(5):540-550. https://doi.org/10.1080/13803395.2014.913554

Author

Hartikainen, Kaisa M. ; Sun, Lihua ; Polvivaara, Markus ; Brause, Maarja ; Lehtimäki, Kai ; Haapasalo, Joonas ; Möttönen, Timo ; Väyrynen, Kirsi ; Ogawa, Keith H. ; Öhman, Juha ; Peltola, Jukka. / Immediate effects of deep brain stimulation of anterior thalamic nuclei on executive functions and emotion-attention interaction in humans. Julkaisussa: JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY. 2014 ; Vuosikerta 36, Nro 5. Sivut 540-550.

Bibtex - Lataa

@article{d1f118f229ea40b58b707fae63805885,
title = "Immediate effects of deep brain stimulation of anterior thalamic nuclei on executive functions and emotion-attention interaction in humans",
abstract = "Background: Deep brain stimulation (DBS) of anterior thalamic nuclei (ANT) is a novel promising therapeutic method for treating refractory epilepsy. Despite reports of subjective memory impairments and mood disturbances in patients with ANT-DBS, little is known of its effects on cognitive and affective processes. Hypothesis: The anterior thalamus has connections to prefrontal and limbic networks important for cognitive control and emotional reactivity. More specifically, anterior cingulate cortex (ACC), linked with ANT, has been assigned roles related to response inhibition and attention allocation to threat. Thus, we hypothesized ANT-DBS to influence executive functions, particularly response inhibition, and modulate emotional reactivity to threat. Method: Twelve patients having undergone ANT-DBS for intractable epilepsy participated in the study. Patients performed a computer-based executive reaction time (RT) test - that is, a go/no-go visual discrimination task with threat-related emotional distractors and rule switching, while the DBS was switched ON (5/5 mA constant current) and OFF every few minutes. Results: ANT-DBS increased the amount of commission errors - that is, errors where subjects failed to withhold from responding. Furthermore, ANT-DBS slowed RTs in context of threat-related distractors. When stimulation was turned off, threat-related distractors had no distinct effect on RTs. Conclusion: We found immediate objective effects of ANT-DBS on human cognitive control and emotion-attention interaction. We suggest that ANT-DBS compromised response inhibition and enhanced attention allocation to threat due to altered functioning of neural networks that involve the DBS-target, ANT, and the regions connected to it such as ACC. The results highlight the need to consider affective and cognitive side-effects in addition to the therapeutic effect when adjusting stimulation parameters. Furthermore, this study introduces a novel window into cognitive and affective processes by modulating the associative and limbic networks with direct stimulation of key nodes in the thalamus.",
keywords = "Anterior thalamic nuclei, Deep brain stimulation, Emotion, epilepsy, Executive functions",
author = "Hartikainen, {Kaisa M.} and Lihua Sun and Markus Polvivaara and Maarja Brause and Kai Lehtim{\"a}ki and Joonas Haapasalo and Timo M{\"o}tt{\"o}nen and Kirsi V{\"a}yrynen and Ogawa, {Keith H.} and Juha {\"O}hman and Jukka Peltola",
year = "2014",
month = "5",
day = "28",
doi = "10.1080/13803395.2014.913554",
language = "English",
volume = "36",
pages = "540--550",
journal = "JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY",
issn = "1380-3395",
publisher = "Taylor & Francis",
number = "5",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Immediate effects of deep brain stimulation of anterior thalamic nuclei on executive functions and emotion-attention interaction in humans

AU - Hartikainen, Kaisa M.

AU - Sun, Lihua

AU - Polvivaara, Markus

AU - Brause, Maarja

AU - Lehtimäki, Kai

AU - Haapasalo, Joonas

AU - Möttönen, Timo

AU - Väyrynen, Kirsi

AU - Ogawa, Keith H.

AU - Öhman, Juha

AU - Peltola, Jukka

PY - 2014/5/28

Y1 - 2014/5/28

N2 - Background: Deep brain stimulation (DBS) of anterior thalamic nuclei (ANT) is a novel promising therapeutic method for treating refractory epilepsy. Despite reports of subjective memory impairments and mood disturbances in patients with ANT-DBS, little is known of its effects on cognitive and affective processes. Hypothesis: The anterior thalamus has connections to prefrontal and limbic networks important for cognitive control and emotional reactivity. More specifically, anterior cingulate cortex (ACC), linked with ANT, has been assigned roles related to response inhibition and attention allocation to threat. Thus, we hypothesized ANT-DBS to influence executive functions, particularly response inhibition, and modulate emotional reactivity to threat. Method: Twelve patients having undergone ANT-DBS for intractable epilepsy participated in the study. Patients performed a computer-based executive reaction time (RT) test - that is, a go/no-go visual discrimination task with threat-related emotional distractors and rule switching, while the DBS was switched ON (5/5 mA constant current) and OFF every few minutes. Results: ANT-DBS increased the amount of commission errors - that is, errors where subjects failed to withhold from responding. Furthermore, ANT-DBS slowed RTs in context of threat-related distractors. When stimulation was turned off, threat-related distractors had no distinct effect on RTs. Conclusion: We found immediate objective effects of ANT-DBS on human cognitive control and emotion-attention interaction. We suggest that ANT-DBS compromised response inhibition and enhanced attention allocation to threat due to altered functioning of neural networks that involve the DBS-target, ANT, and the regions connected to it such as ACC. The results highlight the need to consider affective and cognitive side-effects in addition to the therapeutic effect when adjusting stimulation parameters. Furthermore, this study introduces a novel window into cognitive and affective processes by modulating the associative and limbic networks with direct stimulation of key nodes in the thalamus.

AB - Background: Deep brain stimulation (DBS) of anterior thalamic nuclei (ANT) is a novel promising therapeutic method for treating refractory epilepsy. Despite reports of subjective memory impairments and mood disturbances in patients with ANT-DBS, little is known of its effects on cognitive and affective processes. Hypothesis: The anterior thalamus has connections to prefrontal and limbic networks important for cognitive control and emotional reactivity. More specifically, anterior cingulate cortex (ACC), linked with ANT, has been assigned roles related to response inhibition and attention allocation to threat. Thus, we hypothesized ANT-DBS to influence executive functions, particularly response inhibition, and modulate emotional reactivity to threat. Method: Twelve patients having undergone ANT-DBS for intractable epilepsy participated in the study. Patients performed a computer-based executive reaction time (RT) test - that is, a go/no-go visual discrimination task with threat-related emotional distractors and rule switching, while the DBS was switched ON (5/5 mA constant current) and OFF every few minutes. Results: ANT-DBS increased the amount of commission errors - that is, errors where subjects failed to withhold from responding. Furthermore, ANT-DBS slowed RTs in context of threat-related distractors. When stimulation was turned off, threat-related distractors had no distinct effect on RTs. Conclusion: We found immediate objective effects of ANT-DBS on human cognitive control and emotion-attention interaction. We suggest that ANT-DBS compromised response inhibition and enhanced attention allocation to threat due to altered functioning of neural networks that involve the DBS-target, ANT, and the regions connected to it such as ACC. The results highlight the need to consider affective and cognitive side-effects in addition to the therapeutic effect when adjusting stimulation parameters. Furthermore, this study introduces a novel window into cognitive and affective processes by modulating the associative and limbic networks with direct stimulation of key nodes in the thalamus.

KW - Anterior thalamic nuclei

KW - Deep brain stimulation

KW - Emotion

KW - epilepsy

KW - Executive functions

UR - http://www.scopus.com/inward/record.url?scp=84901847878&partnerID=8YFLogxK

U2 - 10.1080/13803395.2014.913554

DO - 10.1080/13803395.2014.913554

M3 - Article

VL - 36

SP - 540

EP - 550

JO - JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY

JF - JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY

SN - 1380-3395

IS - 5

ER -