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Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women

Tutkimustuotosvertaisarvioitu

Standard

Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women. / Kangas, Pauliina; Tahvanainen, Anna; Tikkakoski, Antti; Koskela, Jenni; Uitto, Marko; Viik, Jari; Kähönen, Mika; Kööbi, Tiit; Mustonen, Jukka; Pörsti, Ilkka.

julkaisussa: Journal of the American Heart Association, Vuosikerta 5, Nro 6, e002883, 2016.

Tutkimustuotosvertaisarvioitu

Harvard

Kangas, P, Tahvanainen, A, Tikkakoski, A, Koskela, J, Uitto, M, Viik, J, Kähönen, M, Kööbi, T, Mustonen, J & Pörsti, I 2016, 'Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women', Journal of the American Heart Association, Vuosikerta. 5, Nro 6, e002883. https://doi.org/10.1161/JAHA.115.002883

APA

Kangas, P., Tahvanainen, A., Tikkakoski, A., Koskela, J., Uitto, M., Viik, J., ... Pörsti, I. (2016). Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women. Journal of the American Heart Association, 5(6), [ e002883]. https://doi.org/10.1161/JAHA.115.002883

Vancouver

Kangas P, Tahvanainen A, Tikkakoski A, Koskela J, Uitto M, Viik J et al. Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women. Journal of the American Heart Association. 2016;5(6). e002883. https://doi.org/10.1161/JAHA.115.002883

Author

Kangas, Pauliina ; Tahvanainen, Anna ; Tikkakoski, Antti ; Koskela, Jenni ; Uitto, Marko ; Viik, Jari ; Kähönen, Mika ; Kööbi, Tiit ; Mustonen, Jukka ; Pörsti, Ilkka. / Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women. Julkaisussa: Journal of the American Heart Association. 2016 ; Vuosikerta 5, Nro 6.

Bibtex - Lataa

@article{b187e9347e9e44a78d6ecc4bb8024f0c,
title = "Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women",
abstract = "Background Men and women differ in the risk of cardiovascular disease, but the underlying mechanisms are not completely understood. We examined possible sex‐related differences in supine and upright cardiovascular regulation. Methods and Results Hemodynamics were recorded from 167 men and 167 women of matching age (≈45 years) and body mass index (≈26.5) during passive head‐up tilt. None had diabetes mellitus or cardiovascular disease other than hypertension or used antihypertensive medication. Whole‐body impedance cardiography, tonometric radial blood pressure, and heart rate variability were analyzed. Results were adjusted for height, smoking, alcohol intake, mean arterial pressure, plasma lipids, and glucose. Supine hemodynamic differences were minor: Men had lower heart rate (−4{\%}) and higher stroke index (+7.5{\%}) than women (P<0.05 for both). Upright systemic vascular resistance was lower (−10{\%}), but stroke index (+15{\%}), cardiac index (+16{\%}), and left cardiac work were clearly higher (+20{\%}) in men than in women (P<0.001 for all). Corresponding results were observed in a subgroup of men and postmenopausal women (n=76, aged >55 years). Heart rate variability analyses showed higher low:high frequency ratios in supine (P<0.001) and upright (P=0.003) positions in men. Conclusions The foremost difference in cardiovascular regulation between sexes was higher upright hemodynamic workload for the heart in men, a finding not explained by known cardiovascular risk factors or hormonal differences before menopause. Heart rate variability analyses indicated higher sympathovagal balance in men regardless of body position. The deviations in upright hemodynamics could play a role in the differences in cardiovascular risk between men and women.",
author = "Pauliina Kangas and Anna Tahvanainen and Antti Tikkakoski and Jenni Koskela and Marko Uitto and Jari Viik and Mika K{\"a}h{\"o}nen and Tiit K{\"o}{\"o}bi and Jukka Mustonen and Ilkka P{\"o}rsti",
year = "2016",
doi = "10.1161/JAHA.115.002883",
language = "English",
volume = "5",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "American Heart Association",
number = "6",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women

AU - Kangas, Pauliina

AU - Tahvanainen, Anna

AU - Tikkakoski, Antti

AU - Koskela, Jenni

AU - Uitto, Marko

AU - Viik, Jari

AU - Kähönen, Mika

AU - Kööbi, Tiit

AU - Mustonen, Jukka

AU - Pörsti, Ilkka

PY - 2016

Y1 - 2016

N2 - Background Men and women differ in the risk of cardiovascular disease, but the underlying mechanisms are not completely understood. We examined possible sex‐related differences in supine and upright cardiovascular regulation. Methods and Results Hemodynamics were recorded from 167 men and 167 women of matching age (≈45 years) and body mass index (≈26.5) during passive head‐up tilt. None had diabetes mellitus or cardiovascular disease other than hypertension or used antihypertensive medication. Whole‐body impedance cardiography, tonometric radial blood pressure, and heart rate variability were analyzed. Results were adjusted for height, smoking, alcohol intake, mean arterial pressure, plasma lipids, and glucose. Supine hemodynamic differences were minor: Men had lower heart rate (−4%) and higher stroke index (+7.5%) than women (P<0.05 for both). Upright systemic vascular resistance was lower (−10%), but stroke index (+15%), cardiac index (+16%), and left cardiac work were clearly higher (+20%) in men than in women (P<0.001 for all). Corresponding results were observed in a subgroup of men and postmenopausal women (n=76, aged >55 years). Heart rate variability analyses showed higher low:high frequency ratios in supine (P<0.001) and upright (P=0.003) positions in men. Conclusions The foremost difference in cardiovascular regulation between sexes was higher upright hemodynamic workload for the heart in men, a finding not explained by known cardiovascular risk factors or hormonal differences before menopause. Heart rate variability analyses indicated higher sympathovagal balance in men regardless of body position. The deviations in upright hemodynamics could play a role in the differences in cardiovascular risk between men and women.

AB - Background Men and women differ in the risk of cardiovascular disease, but the underlying mechanisms are not completely understood. We examined possible sex‐related differences in supine and upright cardiovascular regulation. Methods and Results Hemodynamics were recorded from 167 men and 167 women of matching age (≈45 years) and body mass index (≈26.5) during passive head‐up tilt. None had diabetes mellitus or cardiovascular disease other than hypertension or used antihypertensive medication. Whole‐body impedance cardiography, tonometric radial blood pressure, and heart rate variability were analyzed. Results were adjusted for height, smoking, alcohol intake, mean arterial pressure, plasma lipids, and glucose. Supine hemodynamic differences were minor: Men had lower heart rate (−4%) and higher stroke index (+7.5%) than women (P<0.05 for both). Upright systemic vascular resistance was lower (−10%), but stroke index (+15%), cardiac index (+16%), and left cardiac work were clearly higher (+20%) in men than in women (P<0.001 for all). Corresponding results were observed in a subgroup of men and postmenopausal women (n=76, aged >55 years). Heart rate variability analyses showed higher low:high frequency ratios in supine (P<0.001) and upright (P=0.003) positions in men. Conclusions The foremost difference in cardiovascular regulation between sexes was higher upright hemodynamic workload for the heart in men, a finding not explained by known cardiovascular risk factors or hormonal differences before menopause. Heart rate variability analyses indicated higher sympathovagal balance in men regardless of body position. The deviations in upright hemodynamics could play a role in the differences in cardiovascular risk between men and women.

U2 - 10.1161/JAHA.115.002883

DO - 10.1161/JAHA.115.002883

M3 - Article

VL - 5

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 6

M1 - e002883

ER -