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Information transfer in QT-RR dynamics: Application to QT-correction

Tutkimustuotosvertaisarvioitu

Standard

Information transfer in QT-RR dynamics : Application to QT-correction. / Potapov, Ilya; Latukka, Joonas; Kim, Jiyeong; Luukko, Perttu; Aalto-Setälä, Katriina; Räsänen, Esa.

julkaisussa: Scientific Reports, Vuosikerta 8, Nro 1, 14992, 01.12.2018.

Tutkimustuotosvertaisarvioitu

Harvard

Potapov, I, Latukka, J, Kim, J, Luukko, P, Aalto-Setälä, K & Räsänen, E 2018, 'Information transfer in QT-RR dynamics: Application to QT-correction', Scientific Reports, Vuosikerta. 8, Nro 1, 14992. https://doi.org/10.1038/s41598-018-33359-1

APA

Potapov, I., Latukka, J., Kim, J., Luukko, P., Aalto-Setälä, K., & Räsänen, E. (2018). Information transfer in QT-RR dynamics: Application to QT-correction. Scientific Reports, 8(1), [14992]. https://doi.org/10.1038/s41598-018-33359-1

Vancouver

Potapov I, Latukka J, Kim J, Luukko P, Aalto-Setälä K, Räsänen E. Information transfer in QT-RR dynamics: Application to QT-correction. Scientific Reports. 2018 joulu 1;8(1). 14992. https://doi.org/10.1038/s41598-018-33359-1

Author

Potapov, Ilya ; Latukka, Joonas ; Kim, Jiyeong ; Luukko, Perttu ; Aalto-Setälä, Katriina ; Räsänen, Esa. / Information transfer in QT-RR dynamics : Application to QT-correction. Julkaisussa: Scientific Reports. 2018 ; Vuosikerta 8, Nro 1.

Bibtex - Lataa

@article{3bf60ef9e6e24e3c99b25d94d7091f5c,
title = "Information transfer in QT-RR dynamics: Application to QT-correction",
abstract = "The relation between the electrical properties of the heart and the beating rate is essential for the heart functioning. This relation is central when calculating the “corrected QT interval” — an important measure of the risk of potentially lethal arrhythmias. We use the transfer entropy method from information theory to quantitatively study the mutual dynamics of the ventricular action potential duration (the QT interval) and the length of the beat-to-beat (RR) interval. We show that for healthy individuals there is a strong asymmetry in the information transfer: the information flow from RR to QT dominates over the opposite flow (from QT to RR), i.e. QT depends on RR to a larger extent than RR on QT. Moreover, the history of the intervals has a strong effect on the information transfer: at sufficiently long QT history length the information flow asymmetry inverts and the RR influence on QT dynamics weakens. Finally, we demonstrate that the widely used QT correction methods cannot properly capture the changes in the information flows between QT and RR. We conclude that our results obtained through a model-free informational perspective can be utilised to improve and test the QT correction schemes in clinics.",
author = "Ilya Potapov and Joonas Latukka and Jiyeong Kim and Perttu Luukko and Katriina Aalto-Set{\"a}l{\"a} and Esa R{\"a}s{\"a}nen",
year = "2018",
month = "12",
day = "1",
doi = "10.1038/s41598-018-33359-1",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Information transfer in QT-RR dynamics

T2 - Application to QT-correction

AU - Potapov, Ilya

AU - Latukka, Joonas

AU - Kim, Jiyeong

AU - Luukko, Perttu

AU - Aalto-Setälä, Katriina

AU - Räsänen, Esa

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The relation between the electrical properties of the heart and the beating rate is essential for the heart functioning. This relation is central when calculating the “corrected QT interval” — an important measure of the risk of potentially lethal arrhythmias. We use the transfer entropy method from information theory to quantitatively study the mutual dynamics of the ventricular action potential duration (the QT interval) and the length of the beat-to-beat (RR) interval. We show that for healthy individuals there is a strong asymmetry in the information transfer: the information flow from RR to QT dominates over the opposite flow (from QT to RR), i.e. QT depends on RR to a larger extent than RR on QT. Moreover, the history of the intervals has a strong effect on the information transfer: at sufficiently long QT history length the information flow asymmetry inverts and the RR influence on QT dynamics weakens. Finally, we demonstrate that the widely used QT correction methods cannot properly capture the changes in the information flows between QT and RR. We conclude that our results obtained through a model-free informational perspective can be utilised to improve and test the QT correction schemes in clinics.

AB - The relation between the electrical properties of the heart and the beating rate is essential for the heart functioning. This relation is central when calculating the “corrected QT interval” — an important measure of the risk of potentially lethal arrhythmias. We use the transfer entropy method from information theory to quantitatively study the mutual dynamics of the ventricular action potential duration (the QT interval) and the length of the beat-to-beat (RR) interval. We show that for healthy individuals there is a strong asymmetry in the information transfer: the information flow from RR to QT dominates over the opposite flow (from QT to RR), i.e. QT depends on RR to a larger extent than RR on QT. Moreover, the history of the intervals has a strong effect on the information transfer: at sufficiently long QT history length the information flow asymmetry inverts and the RR influence on QT dynamics weakens. Finally, we demonstrate that the widely used QT correction methods cannot properly capture the changes in the information flows between QT and RR. We conclude that our results obtained through a model-free informational perspective can be utilised to improve and test the QT correction schemes in clinics.

U2 - 10.1038/s41598-018-33359-1

DO - 10.1038/s41598-018-33359-1

M3 - Article

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 14992

ER -