TUTCRIS - Tampereen teknillinen yliopisto

TUTCRIS

Iterative reconstruction method based on median root prior in quantification with PET

Tutkimustuotosvertaisarvioitu

Yksityiskohdat

AlkuperäiskieliEnglanti
OtsikkoPositron Emission Tomography in the Millennium
ToimittajatN Tamaki, E Tsukamoto, Y Kuge, C Katoh, K Morita
JulkaisupaikkaAmsterdam
KustantajaElsevier Science Publishers B.V.
Sivut265-270
Sivumäärä6
ISBN (painettu)0-444-50385-4
TilaJulkaistu - 2000
Julkaistu ulkoisestiKyllä
OKM-julkaisutyyppiA4 Artikkeli konferenssijulkaisussa
TapahtumaInternational Positron Emission Tomography Symposium (PET) - SAPPORO, Japani
Kesto: 24 syyskuuta 199926 syyskuuta 1999

Julkaisusarja

NimiINTERNATIONAL CONGRESS SERIES
KustantajaELSEVIER SCIENCE BV
Vuosikerta1197
ISSN (painettu)0531-5131

Conference

ConferenceInternational Positron Emission Tomography Symposium (PET)
MaaJapani
Ajanjakso24/09/9926/09/99

Tiivistelmä

The aim of this study was to compare reproducibility and accuracy of two reconstruction methods in quantification of regional myocardial blood flow (rMBF) and oxygen metabolism with [O-15] labeled tracers and positron emission tomography (PET). A new iterative Bayesian reconstruction method based on median root prior (MRP) was compared with filtered back-projection (FBP) method.

Methods, rMBF, oxygen extraction fraction (rOEF) and myocardial metabolic rate of oxygen consumption (rMMRO(2)) were quantified from images reconstructed using both MRP and FBP in 27 subjects. For each subject, regions of interest (ROIs) were drawn on the lateral, anterior and septal regions on four planes. To test the reproducibility, the ROI drawing procedure was repeated. Using two sets of ROIs, variability was evaluated with MRP and FBP images.

Results. Correlation coefficients of rMBF rOEF and rMMRO(2) were significantly higher in MRP images than in FBP images. Coefficient of variations for each parameter was significantly lower in MRP images than in FBP.

Conclusion. MRP reconstruction provides higher reproducibility and lower variability in the quantitative myocardial parameters compared with FBP. This study presents that the new MRP reconstruction improves accuracy and stability of clinical quantification of myocardial blood flow and oxygen metabolism with [O-15] and PET.