TUTCRIS - Tampereen teknillinen yliopisto

TUTCRIS

La thérapie photodynamique: État de l'art et perspectives

Tutkimustuotosvertaisarvioitu

Yksityiskohdat

AlkuperäiskieliRanska
Sivut46-50
Sivumäärä5
JulkaisuACTUALITE CHIMIQUE
Numero397-398
TilaJulkaistu - 1 kesäkuuta 2015
OKM-julkaisutyyppiA1 Alkuperäisartikkeli

Tiivistelmä

Photodynamic therapy (PDT) is a method of medical treatment using the concomitant action of a photoactivatable molecule called the photosensitizer (PS), light, and oxygen naturally present in the biological medium. After light excitation of the photosensitizer, an energy transfer to oxygen allows to generate the formation of reactive oxygen species, especially singlet oxygen reactive leading to cell death. This technique proves to be very efficient for certain types of cancer (especially in dermatology) and is promising in other pathologies (prostate, brain). This article briefly describes the principle of PDT and then analyzes the latest advances in PDT in terms of clinical applications (actinic keratoses, prostate, brain cancer, retinoblastoma) and the use of PDT for antibacterial applications. Finally, the prospects of this technique with among others the development of new vesicles or the use of X-rays as a source of energy to overcome the problems of light penetration in tissues are presented.

!!ASJC Scopus subject areas

Tutkimusalat