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MicroRNAs in atherosclerosis

Tutkimustuotosvertaisarvioitu

Standard

MicroRNAs in atherosclerosis. / Hosin, Ali A.; Prasad, Anoop; Viiri, Leena E.; Davies, Alun H.; Shalhoub, Joseph.

julkaisussa: Journal of Vascular Research, Vuosikerta 51, Nro 5, 06.02.2014, s. 338-349.

Tutkimustuotosvertaisarvioitu

Harvard

Hosin, AA, Prasad, A, Viiri, LE, Davies, AH & Shalhoub, J 2014, 'MicroRNAs in atherosclerosis', Journal of Vascular Research, Vuosikerta. 51, Nro 5, Sivut 338-349. https://doi.org/10.1159/000368193

APA

Hosin, A. A., Prasad, A., Viiri, L. E., Davies, A. H., & Shalhoub, J. (2014). MicroRNAs in atherosclerosis. Journal of Vascular Research, 51(5), 338-349. https://doi.org/10.1159/000368193

Vancouver

Hosin AA, Prasad A, Viiri LE, Davies AH, Shalhoub J. MicroRNAs in atherosclerosis. Journal of Vascular Research. 2014 helmi 6;51(5):338-349. https://doi.org/10.1159/000368193

Author

Hosin, Ali A. ; Prasad, Anoop ; Viiri, Leena E. ; Davies, Alun H. ; Shalhoub, Joseph. / MicroRNAs in atherosclerosis. Julkaisussa: Journal of Vascular Research. 2014 ; Vuosikerta 51, Nro 5. Sivut 338-349.

Bibtex - Lataa

@article{aabd871b3a0f4c869dc26447f8b64954,
title = "MicroRNAs in atherosclerosis",
abstract = "Micro-ribonucleic acids (miRNAs) are a class of endogenous non-coding ribonucleic acids that regulate gene expression. MiRNAs have been shown to act as key regulators in the vascular system, with wide-ranging physio-pathological effects. Atherosclerotic disease is a leading cause of morbidity and mortality worldwide. This review presents current knowledge on miRNAs implicated in atherosclerosis susceptibility, development and progression. They are involved in cell phenotype switching, response to shear stress, cell senescence, adhesion molecule expression, macrophage response to oxidised low-density lipoprotein, Toll-like receptor 4 expression, neointimal lesion formation, plaque angiogenesis and cellular cholesterol homeostasis. Clinically, early work has demonstrated the utility of miRNAs for differentiating patients with arterial disease from controls and predicting future cardiac events; this highlights potential diagnostic and prognostic roles. MiRNA involvement in the crucial stages of atherosclerosis promises new hope in treating arterial disease. However, issues regarding multiple miRNA targets, stability and delivery continue to present challenges.",
keywords = "Atherosclerosis, Cardiovascular disease, Metabolism, MicroRNA, Vascular smooth muscle cells",
author = "Hosin, {Ali A.} and Anoop Prasad and Viiri, {Leena E.} and Davies, {Alun H.} and Joseph Shalhoub",
year = "2014",
month = "2",
day = "6",
doi = "10.1159/000368193",
language = "English",
volume = "51",
pages = "338--349",
journal = "Journal of Vascular Research",
issn = "1018-1172",
publisher = "Karger",
number = "5",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - MicroRNAs in atherosclerosis

AU - Hosin, Ali A.

AU - Prasad, Anoop

AU - Viiri, Leena E.

AU - Davies, Alun H.

AU - Shalhoub, Joseph

PY - 2014/2/6

Y1 - 2014/2/6

N2 - Micro-ribonucleic acids (miRNAs) are a class of endogenous non-coding ribonucleic acids that regulate gene expression. MiRNAs have been shown to act as key regulators in the vascular system, with wide-ranging physio-pathological effects. Atherosclerotic disease is a leading cause of morbidity and mortality worldwide. This review presents current knowledge on miRNAs implicated in atherosclerosis susceptibility, development and progression. They are involved in cell phenotype switching, response to shear stress, cell senescence, adhesion molecule expression, macrophage response to oxidised low-density lipoprotein, Toll-like receptor 4 expression, neointimal lesion formation, plaque angiogenesis and cellular cholesterol homeostasis. Clinically, early work has demonstrated the utility of miRNAs for differentiating patients with arterial disease from controls and predicting future cardiac events; this highlights potential diagnostic and prognostic roles. MiRNA involvement in the crucial stages of atherosclerosis promises new hope in treating arterial disease. However, issues regarding multiple miRNA targets, stability and delivery continue to present challenges.

AB - Micro-ribonucleic acids (miRNAs) are a class of endogenous non-coding ribonucleic acids that regulate gene expression. MiRNAs have been shown to act as key regulators in the vascular system, with wide-ranging physio-pathological effects. Atherosclerotic disease is a leading cause of morbidity and mortality worldwide. This review presents current knowledge on miRNAs implicated in atherosclerosis susceptibility, development and progression. They are involved in cell phenotype switching, response to shear stress, cell senescence, adhesion molecule expression, macrophage response to oxidised low-density lipoprotein, Toll-like receptor 4 expression, neointimal lesion formation, plaque angiogenesis and cellular cholesterol homeostasis. Clinically, early work has demonstrated the utility of miRNAs for differentiating patients with arterial disease from controls and predicting future cardiac events; this highlights potential diagnostic and prognostic roles. MiRNA involvement in the crucial stages of atherosclerosis promises new hope in treating arterial disease. However, issues regarding multiple miRNA targets, stability and delivery continue to present challenges.

KW - Atherosclerosis

KW - Cardiovascular disease

KW - Metabolism

KW - MicroRNA

KW - Vascular smooth muscle cells

UR - http://www.scopus.com/inward/record.url?scp=84917705795&partnerID=8YFLogxK

U2 - 10.1159/000368193

DO - 10.1159/000368193

M3 - Review Article

VL - 51

SP - 338

EP - 349

JO - Journal of Vascular Research

JF - Journal of Vascular Research

SN - 1018-1172

IS - 5

ER -