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Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D

Tutkimustuotosvertaisarvioitu

Standard

Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D. / Acimovic, Jugoslava; Mäki-Marttunen, Tuomo; Havela, Riikka; Teppola, Heidi; Linne, Marja-Leena.

julkaisussa: Eurasip Journal on Bioinformatics and Systems Biology, Vuosikerta 2011, 616382, 2011, s. 1-13.

Tutkimustuotosvertaisarvioitu

Harvard

Acimovic, J, Mäki-Marttunen, T, Havela, R, Teppola, H & Linne, M-L 2011, 'Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D', Eurasip Journal on Bioinformatics and Systems Biology, Vuosikerta. 2011, 616382, Sivut 1-13. https://doi.org/10.1155/2011/616382

APA

Acimovic, J., Mäki-Marttunen, T., Havela, R., Teppola, H., & Linne, M-L. (2011). Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D. Eurasip Journal on Bioinformatics and Systems Biology, 2011, 1-13. [616382]. https://doi.org/10.1155/2011/616382

Vancouver

Acimovic J, Mäki-Marttunen T, Havela R, Teppola H, Linne M-L. Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D. Eurasip Journal on Bioinformatics and Systems Biology. 2011;2011:1-13. 616382. https://doi.org/10.1155/2011/616382

Author

Acimovic, Jugoslava ; Mäki-Marttunen, Tuomo ; Havela, Riikka ; Teppola, Heidi ; Linne, Marja-Leena. / Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D. Julkaisussa: Eurasip Journal on Bioinformatics and Systems Biology. 2011 ; Vuosikerta 2011. Sivut 1-13.

Bibtex - Lataa

@article{fc5960131cc144b2be3825593164e23e,
title = "Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D",
abstract = "We simulate the growth of neuronal networks using the two recently published tools, NETMORPH and CX3D. The goals of the work are (1) to examine and compare the simulation tools, (2) to construct a model of growth of neocortical cultures, and (3) to characterize the changes in network connectivity during growth, using standard graph theoretic methods. Parameters for the neocortical culture are chosen after consulting both the experimental and the computational work presented in the literature. The first (three) weeks in culture are known to be a time of development of extensive dendritic and axonal arbors and establishment of synaptic connections between the neurons. We simulate the growth of networks from day 1 to day 21. It is shown that for the properly selected parameters, the simulators can reproduce the experimentally obtained connectivity. The selected graph theoretic methods can capture the structural changes during growth.",
author = "Jugoslava Acimovic and Tuomo M{\"a}ki-Marttunen and Riikka Havela and Heidi Teppola and Marja-Leena Linne",
note = "ei ut-numeroa 12.10.2013<br/>Contribution: organisation=sgn,FACT1=0.9<br/>Contribution: organisation=mat,FACT2=0.1",
year = "2011",
doi = "10.1155/2011/616382",
language = "English",
volume = "2011",
pages = "1--13",
journal = "Eurasip Journal on Bioinformatics and Systems Biology",
issn = "1687-4145",
publisher = "Springer Verlag",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D

AU - Acimovic, Jugoslava

AU - Mäki-Marttunen, Tuomo

AU - Havela, Riikka

AU - Teppola, Heidi

AU - Linne, Marja-Leena

N1 - ei ut-numeroa 12.10.2013<br/>Contribution: organisation=sgn,FACT1=0.9<br/>Contribution: organisation=mat,FACT2=0.1

PY - 2011

Y1 - 2011

N2 - We simulate the growth of neuronal networks using the two recently published tools, NETMORPH and CX3D. The goals of the work are (1) to examine and compare the simulation tools, (2) to construct a model of growth of neocortical cultures, and (3) to characterize the changes in network connectivity during growth, using standard graph theoretic methods. Parameters for the neocortical culture are chosen after consulting both the experimental and the computational work presented in the literature. The first (three) weeks in culture are known to be a time of development of extensive dendritic and axonal arbors and establishment of synaptic connections between the neurons. We simulate the growth of networks from day 1 to day 21. It is shown that for the properly selected parameters, the simulators can reproduce the experimentally obtained connectivity. The selected graph theoretic methods can capture the structural changes during growth.

AB - We simulate the growth of neuronal networks using the two recently published tools, NETMORPH and CX3D. The goals of the work are (1) to examine and compare the simulation tools, (2) to construct a model of growth of neocortical cultures, and (3) to characterize the changes in network connectivity during growth, using standard graph theoretic methods. Parameters for the neocortical culture are chosen after consulting both the experimental and the computational work presented in the literature. The first (three) weeks in culture are known to be a time of development of extensive dendritic and axonal arbors and establishment of synaptic connections between the neurons. We simulate the growth of networks from day 1 to day 21. It is shown that for the properly selected parameters, the simulators can reproduce the experimentally obtained connectivity. The selected graph theoretic methods can capture the structural changes during growth.

U2 - 10.1155/2011/616382

DO - 10.1155/2011/616382

M3 - Article

VL - 2011

SP - 1

EP - 13

JO - Eurasip Journal on Bioinformatics and Systems Biology

JF - Eurasip Journal on Bioinformatics and Systems Biology

SN - 1687-4145

M1 - 616382

ER -