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Modulating sustained drug release from nanocellulose hydrogel by adjusting the inner geometry of implantable capsules

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Modulating sustained drug release from nanocellulose hydrogel by adjusting the inner geometry of implantable capsules. / Auvinen, Vili Veli; Virtanen, Juhani; Merivaara, Arto; Virtanen, Valtteri; Laurén, Patrick; Tuukkanen, Sampo; Laaksonen, Timo.

julkaisussa: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, Vuosikerta 57, 101625, 2020.

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Auvinen, Vili Veli ; Virtanen, Juhani ; Merivaara, Arto ; Virtanen, Valtteri ; Laurén, Patrick ; Tuukkanen, Sampo ; Laaksonen, Timo. / Modulating sustained drug release from nanocellulose hydrogel by adjusting the inner geometry of implantable capsules. Julkaisussa: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. 2020 ; Vuosikerta 57.

Bibtex - Lataa

@article{f4f77106ba124f4f84716f004bb63f15,
title = "Modulating sustained drug release from nanocellulose hydrogel by adjusting the inner geometry of implantable capsules",
abstract = "Nanocellulose hydrogel has been shown to be an excellent platform for drug delivery and it has been lately studied as an injectable drug carrier. 3D printing is an effective method for fast prototyping of pharmaceutical devices with unique shape and cavities enabling new types of controlled release. In this study, we combined the versatility of 3D printing capsules with controlled geometry and the drug release properties of nanocellulose hydrogel to accurately modulate its drug release properties. We first manufactured non-active capsules via 3D printing from biocompatible poly(lactic acid) (PLA) that limit the direction of drug diffusion. As a novel method, the capsules were filled with a drug dispersion composed of model compounds and anionic cellulose nanofiber (CNF) hydrogel. The main benefit of this device is that the release of any CNF-compatible drug can be modulated simply by modulating the inner geometry of the PLA capsule. In the study we optimized the size and shape of the capsules inner cavity and performed drug release tests with common beta blockers metoprolol and nadolol as the model compounds. The results demonstrate that the sustained release profiles provided by the CNF matrix can be accurately modulated via adjusting the geometry of the 3D printed PLA capsule, resulting in adjustable sustained release for the model compounds.",
keywords = "3D printing, Hydrogel, Nanocellulose, Sustained drug release",
author = "Auvinen, {Vili Veli} and Juhani Virtanen and Arto Merivaara and Valtteri Virtanen and Patrick Laur{\'e}n and Sampo Tuukkanen and Timo Laaksonen",
note = "INT=bmte,{"}Virtanen, Valtteri{"}",
year = "2020",
doi = "10.1016/j.jddst.2020.101625",
language = "English",
volume = "57",
journal = "JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY",
issn = "1773-2247",
publisher = "Editions de Sante",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Modulating sustained drug release from nanocellulose hydrogel by adjusting the inner geometry of implantable capsules

AU - Auvinen, Vili Veli

AU - Virtanen, Juhani

AU - Merivaara, Arto

AU - Virtanen, Valtteri

AU - Laurén, Patrick

AU - Tuukkanen, Sampo

AU - Laaksonen, Timo

N1 - INT=bmte,"Virtanen, Valtteri"

PY - 2020

Y1 - 2020

N2 - Nanocellulose hydrogel has been shown to be an excellent platform for drug delivery and it has been lately studied as an injectable drug carrier. 3D printing is an effective method for fast prototyping of pharmaceutical devices with unique shape and cavities enabling new types of controlled release. In this study, we combined the versatility of 3D printing capsules with controlled geometry and the drug release properties of nanocellulose hydrogel to accurately modulate its drug release properties. We first manufactured non-active capsules via 3D printing from biocompatible poly(lactic acid) (PLA) that limit the direction of drug diffusion. As a novel method, the capsules were filled with a drug dispersion composed of model compounds and anionic cellulose nanofiber (CNF) hydrogel. The main benefit of this device is that the release of any CNF-compatible drug can be modulated simply by modulating the inner geometry of the PLA capsule. In the study we optimized the size and shape of the capsules inner cavity and performed drug release tests with common beta blockers metoprolol and nadolol as the model compounds. The results demonstrate that the sustained release profiles provided by the CNF matrix can be accurately modulated via adjusting the geometry of the 3D printed PLA capsule, resulting in adjustable sustained release for the model compounds.

AB - Nanocellulose hydrogel has been shown to be an excellent platform for drug delivery and it has been lately studied as an injectable drug carrier. 3D printing is an effective method for fast prototyping of pharmaceutical devices with unique shape and cavities enabling new types of controlled release. In this study, we combined the versatility of 3D printing capsules with controlled geometry and the drug release properties of nanocellulose hydrogel to accurately modulate its drug release properties. We first manufactured non-active capsules via 3D printing from biocompatible poly(lactic acid) (PLA) that limit the direction of drug diffusion. As a novel method, the capsules were filled with a drug dispersion composed of model compounds and anionic cellulose nanofiber (CNF) hydrogel. The main benefit of this device is that the release of any CNF-compatible drug can be modulated simply by modulating the inner geometry of the PLA capsule. In the study we optimized the size and shape of the capsules inner cavity and performed drug release tests with common beta blockers metoprolol and nadolol as the model compounds. The results demonstrate that the sustained release profiles provided by the CNF matrix can be accurately modulated via adjusting the geometry of the 3D printed PLA capsule, resulting in adjustable sustained release for the model compounds.

KW - 3D printing

KW - Hydrogel

KW - Nanocellulose

KW - Sustained drug release

U2 - 10.1016/j.jddst.2020.101625

DO - 10.1016/j.jddst.2020.101625

M3 - Article

VL - 57

JO - JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

JF - JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

SN - 1773-2247

M1 - 101625

ER -