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Noninvasive Cardiorespiratory Signals Analysis for Asthma Evolution Monitoring in Preschool Children

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Standard

Noninvasive Cardiorespiratory Signals Analysis for Asthma Evolution Monitoring in Preschool Children. / Milagro, Javier; Gracia, Javier; Seppä, Ville-Pekka; Karjalainen, Jussi; Paassilta, Marita; Orini, Michele; Bailón, Raquel; Gil, Eduardo; Viik, Jari.

julkaisussa: IEEE Transactions on Biomedical Engineering, 28.10.2019.

Tutkimustuotosvertaisarvioitu

Harvard

Milagro, J, Gracia, J, Seppä, V-P, Karjalainen, J, Paassilta, M, Orini, M, Bailón, R, Gil, E & Viik, J 2019, 'Noninvasive Cardiorespiratory Signals Analysis for Asthma Evolution Monitoring in Preschool Children', IEEE Transactions on Biomedical Engineering. https://doi.org/10.1109/TBME.2019.2949873

APA

Milagro, J., Gracia, J., Seppä, V-P., Karjalainen, J., Paassilta, M., Orini, M., ... Viik, J. (2019). Noninvasive Cardiorespiratory Signals Analysis for Asthma Evolution Monitoring in Preschool Children. IEEE Transactions on Biomedical Engineering. https://doi.org/10.1109/TBME.2019.2949873

Vancouver

Milagro J, Gracia J, Seppä V-P, Karjalainen J, Paassilta M, Orini M et al. Noninvasive Cardiorespiratory Signals Analysis for Asthma Evolution Monitoring in Preschool Children. IEEE Transactions on Biomedical Engineering. 2019 loka 28. https://doi.org/10.1109/TBME.2019.2949873

Author

Milagro, Javier ; Gracia, Javier ; Seppä, Ville-Pekka ; Karjalainen, Jussi ; Paassilta, Marita ; Orini, Michele ; Bailón, Raquel ; Gil, Eduardo ; Viik, Jari. / Noninvasive Cardiorespiratory Signals Analysis for Asthma Evolution Monitoring in Preschool Children. Julkaisussa: IEEE Transactions on Biomedical Engineering. 2019.

Bibtex - Lataa

@article{1db2148893724f719a02bb519310bef6,
title = "Noninvasive Cardiorespiratory Signals Analysis for Asthma Evolution Monitoring in Preschool Children",
abstract = "Objective: Despite its increasing prevalence, diagnosis of asthma in children remains problematic due to their difficulties in producing repeatable spirometric maneuvers. Moreover, low adherence to inhaled corticosteroids (ICS) treatment could result in permanent airway remodeling. The growing interest in a noninvasive and objective way for monitoring asthma, together with the apparent role of autonomic nervous system (ANS) in its pathogenesis, have attracted interest towards heart rate variability (HRV) and cardiorespiratory coupling (CRC) analyses. Methods: HRV and CRC were analyzed in 70 children who were prescribed ICS treatment due to recurrent obstructive bronchitis. They underwent three different electrocardiogram and respiratory signals recordings, during and after treatment period. After treatment completion, they were followed up during 6 months and classified attending to their current asthma status. Results: Vagal activity, as measured from HRV, and CRC, were reduced after treatment in those children at lower risk of asthma, whereas it kept unchanged in those with a worse prognosis. Conclusion: Results suggest that HRV analysis could be useful for the continuous monitoring of ANS anomalies present in asthma, thus contributing to evaluate the evolution of the disease, which is especially challenging in young children. Significance: Noninvasive ANS assessment using HRV analysis could be useful in the continuous monitoring of asthma in children.",
keywords = "Respiratory system, Heart rate variability, Integrated circuits, Monitoring, Pediatrics, IP networks, Signal to noise ratio, asthma, heart rate variability, children, inhaled corticosteroids, obstructive bronchitis",
author = "Javier Milagro and Javier Gracia and Ville-Pekka Sepp{\"a} and Jussi Karjalainen and Marita Paassilta and Michele Orini and Raquel Bail{\'o}n and Eduardo Gil and Jari Viik",
note = "EXT={"}Sepp{\"a}, Ville-Pekka{"}",
year = "2019",
month = "10",
day = "28",
doi = "10.1109/TBME.2019.2949873",
language = "English",
journal = "IEEE Transactions on Biomedical Engineering",
issn = "0018-9294",
publisher = "Institute of Electrical and Electronics Engineers",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Noninvasive Cardiorespiratory Signals Analysis for Asthma Evolution Monitoring in Preschool Children

AU - Milagro, Javier

AU - Gracia, Javier

AU - Seppä, Ville-Pekka

AU - Karjalainen, Jussi

AU - Paassilta, Marita

AU - Orini, Michele

AU - Bailón, Raquel

AU - Gil, Eduardo

AU - Viik, Jari

N1 - EXT="Seppä, Ville-Pekka"

PY - 2019/10/28

Y1 - 2019/10/28

N2 - Objective: Despite its increasing prevalence, diagnosis of asthma in children remains problematic due to their difficulties in producing repeatable spirometric maneuvers. Moreover, low adherence to inhaled corticosteroids (ICS) treatment could result in permanent airway remodeling. The growing interest in a noninvasive and objective way for monitoring asthma, together with the apparent role of autonomic nervous system (ANS) in its pathogenesis, have attracted interest towards heart rate variability (HRV) and cardiorespiratory coupling (CRC) analyses. Methods: HRV and CRC were analyzed in 70 children who were prescribed ICS treatment due to recurrent obstructive bronchitis. They underwent three different electrocardiogram and respiratory signals recordings, during and after treatment period. After treatment completion, they were followed up during 6 months and classified attending to their current asthma status. Results: Vagal activity, as measured from HRV, and CRC, were reduced after treatment in those children at lower risk of asthma, whereas it kept unchanged in those with a worse prognosis. Conclusion: Results suggest that HRV analysis could be useful for the continuous monitoring of ANS anomalies present in asthma, thus contributing to evaluate the evolution of the disease, which is especially challenging in young children. Significance: Noninvasive ANS assessment using HRV analysis could be useful in the continuous monitoring of asthma in children.

AB - Objective: Despite its increasing prevalence, diagnosis of asthma in children remains problematic due to their difficulties in producing repeatable spirometric maneuvers. Moreover, low adherence to inhaled corticosteroids (ICS) treatment could result in permanent airway remodeling. The growing interest in a noninvasive and objective way for monitoring asthma, together with the apparent role of autonomic nervous system (ANS) in its pathogenesis, have attracted interest towards heart rate variability (HRV) and cardiorespiratory coupling (CRC) analyses. Methods: HRV and CRC were analyzed in 70 children who were prescribed ICS treatment due to recurrent obstructive bronchitis. They underwent three different electrocardiogram and respiratory signals recordings, during and after treatment period. After treatment completion, they were followed up during 6 months and classified attending to their current asthma status. Results: Vagal activity, as measured from HRV, and CRC, were reduced after treatment in those children at lower risk of asthma, whereas it kept unchanged in those with a worse prognosis. Conclusion: Results suggest that HRV analysis could be useful for the continuous monitoring of ANS anomalies present in asthma, thus contributing to evaluate the evolution of the disease, which is especially challenging in young children. Significance: Noninvasive ANS assessment using HRV analysis could be useful in the continuous monitoring of asthma in children.

KW - Respiratory system

KW - Heart rate variability

KW - Integrated circuits

KW - Monitoring

KW - Pediatrics

KW - IP networks

KW - Signal to noise ratio

KW - asthma

KW - heart rate variability

KW - children

KW - inhaled corticosteroids

KW - obstructive bronchitis

U2 - 10.1109/TBME.2019.2949873

DO - 10.1109/TBME.2019.2949873

M3 - Article

JO - IEEE Transactions on Biomedical Engineering

JF - IEEE Transactions on Biomedical Engineering

SN - 0018-9294

ER -