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Novel osteoconductive β-tricalcium phosphate/poly(L-lactide-co-e-caprolactone) scaffold for bone regeneration: a study in a rabbit calvarial defect

Tutkimustuotosvertaisarvioitu

Standard

Novel osteoconductive β-tricalcium phosphate/poly(L-lactide-co-e-caprolactone) scaffold for bone regeneration : a study in a rabbit calvarial defect. / Pihlman, Hanna; Keränen, Pauli; Paakinaho, Kaarlo; Linden, Jere; Hannula, Markus; Manninen, Iida Kaisa; Hyttinen, Jari; Manninen, Mikko; Laitinen-Vapaavuori, Outi.

julkaisussa: Journal of Materials Science: Materials in Medicine, Vuosikerta 29, Nro 10, 156, 01.10.2018.

Tutkimustuotosvertaisarvioitu

Harvard

Pihlman, H, Keränen, P, Paakinaho, K, Linden, J, Hannula, M, Manninen, IK, Hyttinen, J, Manninen, M & Laitinen-Vapaavuori, O 2018, 'Novel osteoconductive β-tricalcium phosphate/poly(L-lactide-co-e-caprolactone) scaffold for bone regeneration: a study in a rabbit calvarial defect', Journal of Materials Science: Materials in Medicine, Vuosikerta. 29, Nro 10, 156. https://doi.org/10.1007/s10856-018-6159-9

APA

Pihlman, H., Keränen, P., Paakinaho, K., Linden, J., Hannula, M., Manninen, I. K., ... Laitinen-Vapaavuori, O. (2018). Novel osteoconductive β-tricalcium phosphate/poly(L-lactide-co-e-caprolactone) scaffold for bone regeneration: a study in a rabbit calvarial defect. Journal of Materials Science: Materials in Medicine, 29(10), [156]. https://doi.org/10.1007/s10856-018-6159-9

Vancouver

Pihlman H, Keränen P, Paakinaho K, Linden J, Hannula M, Manninen IK et al. Novel osteoconductive β-tricalcium phosphate/poly(L-lactide-co-e-caprolactone) scaffold for bone regeneration: a study in a rabbit calvarial defect. Journal of Materials Science: Materials in Medicine. 2018 loka 1;29(10). 156. https://doi.org/10.1007/s10856-018-6159-9

Author

Pihlman, Hanna ; Keränen, Pauli ; Paakinaho, Kaarlo ; Linden, Jere ; Hannula, Markus ; Manninen, Iida Kaisa ; Hyttinen, Jari ; Manninen, Mikko ; Laitinen-Vapaavuori, Outi. / Novel osteoconductive β-tricalcium phosphate/poly(L-lactide-co-e-caprolactone) scaffold for bone regeneration : a study in a rabbit calvarial defect. Julkaisussa: Journal of Materials Science: Materials in Medicine. 2018 ; Vuosikerta 29, Nro 10.

Bibtex - Lataa

@article{aad5e94cfacf4788b87fbdc670da5456,
title = "Novel osteoconductive β-tricalcium phosphate/poly(L-lactide-co-e-caprolactone) scaffold for bone regeneration: a study in a rabbit calvarial defect",
abstract = "The advantages of synthetic bone graft substitutes over autogenous bone grafts include abundant graft volume, lack of complications related to the graft harvesting, and shorter operation and recovery times for the patient. We studied a new synthetic supercritical CO2 –processed porous composite scaffold of β-tricalcium phosphate and poly(L-lactide-co-caprolactone) copolymer as a bone graft substitute in a rabbit calvarial defect. Bilateral 12 mm diameter critical size calvarial defects were successfully created in 18 rabbits. The right defect was filled with a scaffold moistened with bone marrow aspirate, and the other was an empty control. The material was assessed for applicability during surgery. The follow-up times were 4, 12, and 24 weeks. Radiographic and micro-CT studies and histopathological analysis were used to evaluate new bone formation, tissue ingrowth, and biocompatibility. The scaffold was easy to shape and handle during the surgery, and the bone-scaffold contact was tight when visually evaluated after the implantation. The material showed good biocompatibility and its porosity enabled rapid invasion of vasculature and full thickness mesenchymal tissue ingrowth already at four weeks. By 24 weeks, full thickness bone ingrowth within the scaffold and along the dura was generally seen. In contrast, the empty defect had only a thin layer of new bone at 24 weeks. The radiodensity of the material was similar to the density of the intact bone. In conclusion, the new porous scaffold material, composed of microgranular β-TCP bound into the polymer matrix, proved to be a promising osteoconductive bone graft substitute with excellent handling properties. [Figure not available: see fulltext.].",
author = "Hanna Pihlman and Pauli Ker{\"a}nen and Kaarlo Paakinaho and Jere Linden and Markus Hannula and Manninen, {Iida Kaisa} and Jari Hyttinen and Mikko Manninen and Outi Laitinen-Vapaavuori",
year = "2018",
month = "10",
day = "1",
doi = "10.1007/s10856-018-6159-9",
language = "English",
volume = "29",
journal = "Journal of Materials Science: Materials in Medicine",
issn = "0957-4530",
publisher = "Springer Verlag",
number = "10",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Novel osteoconductive β-tricalcium phosphate/poly(L-lactide-co-e-caprolactone) scaffold for bone regeneration

T2 - a study in a rabbit calvarial defect

AU - Pihlman, Hanna

AU - Keränen, Pauli

AU - Paakinaho, Kaarlo

AU - Linden, Jere

AU - Hannula, Markus

AU - Manninen, Iida Kaisa

AU - Hyttinen, Jari

AU - Manninen, Mikko

AU - Laitinen-Vapaavuori, Outi

PY - 2018/10/1

Y1 - 2018/10/1

N2 - The advantages of synthetic bone graft substitutes over autogenous bone grafts include abundant graft volume, lack of complications related to the graft harvesting, and shorter operation and recovery times for the patient. We studied a new synthetic supercritical CO2 –processed porous composite scaffold of β-tricalcium phosphate and poly(L-lactide-co-caprolactone) copolymer as a bone graft substitute in a rabbit calvarial defect. Bilateral 12 mm diameter critical size calvarial defects were successfully created in 18 rabbits. The right defect was filled with a scaffold moistened with bone marrow aspirate, and the other was an empty control. The material was assessed for applicability during surgery. The follow-up times were 4, 12, and 24 weeks. Radiographic and micro-CT studies and histopathological analysis were used to evaluate new bone formation, tissue ingrowth, and biocompatibility. The scaffold was easy to shape and handle during the surgery, and the bone-scaffold contact was tight when visually evaluated after the implantation. The material showed good biocompatibility and its porosity enabled rapid invasion of vasculature and full thickness mesenchymal tissue ingrowth already at four weeks. By 24 weeks, full thickness bone ingrowth within the scaffold and along the dura was generally seen. In contrast, the empty defect had only a thin layer of new bone at 24 weeks. The radiodensity of the material was similar to the density of the intact bone. In conclusion, the new porous scaffold material, composed of microgranular β-TCP bound into the polymer matrix, proved to be a promising osteoconductive bone graft substitute with excellent handling properties. [Figure not available: see fulltext.].

AB - The advantages of synthetic bone graft substitutes over autogenous bone grafts include abundant graft volume, lack of complications related to the graft harvesting, and shorter operation and recovery times for the patient. We studied a new synthetic supercritical CO2 –processed porous composite scaffold of β-tricalcium phosphate and poly(L-lactide-co-caprolactone) copolymer as a bone graft substitute in a rabbit calvarial defect. Bilateral 12 mm diameter critical size calvarial defects were successfully created in 18 rabbits. The right defect was filled with a scaffold moistened with bone marrow aspirate, and the other was an empty control. The material was assessed for applicability during surgery. The follow-up times were 4, 12, and 24 weeks. Radiographic and micro-CT studies and histopathological analysis were used to evaluate new bone formation, tissue ingrowth, and biocompatibility. The scaffold was easy to shape and handle during the surgery, and the bone-scaffold contact was tight when visually evaluated after the implantation. The material showed good biocompatibility and its porosity enabled rapid invasion of vasculature and full thickness mesenchymal tissue ingrowth already at four weeks. By 24 weeks, full thickness bone ingrowth within the scaffold and along the dura was generally seen. In contrast, the empty defect had only a thin layer of new bone at 24 weeks. The radiodensity of the material was similar to the density of the intact bone. In conclusion, the new porous scaffold material, composed of microgranular β-TCP bound into the polymer matrix, proved to be a promising osteoconductive bone graft substitute with excellent handling properties. [Figure not available: see fulltext.].

U2 - 10.1007/s10856-018-6159-9

DO - 10.1007/s10856-018-6159-9

M3 - Article

VL - 29

JO - Journal of Materials Science: Materials in Medicine

JF - Journal of Materials Science: Materials in Medicine

SN - 0957-4530

IS - 10

M1 - 156

ER -