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Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress

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Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress. / Latonen, Leena.

julkaisussa: BioEssays, Vuosikerta 33, Nro 5, 05.2011, s. 386-395.

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Latonen, Leena. / Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress. Julkaisussa: BioEssays. 2011 ; Vuosikerta 33, Nro 5. Sivut 386-395.

Bibtex - Lataa

@article{3c5e74d53b55493f937322188713ef23,
title = "Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress",
abstract = "The nucleolus may represent a key stress response organelle in the nucleus following proteotoxic stress by serving as a platform for protein aggregates. Aggregation of proteins often results from insufficient protein degradation by the ubiquitin-proteasome system (UPS), occurring in inclusion diseases, upon treatment by proteasome inhibitors (PIs) or due to various forms of stress. As the nucleolar inclusions resemble cytoplasmic aggresomes in gathering ubiquitin and numerous UPS components and targets, including cancer-related transcription factors and cell cycle regulators (e.g. p53 and cyclin D) and proteins involved in neurodegenerative diseases (e.g. ataxin-1, Malin), these organelles are termed herein as nucleolar aggresomes. These nucleolar aggresomes contain polyadenylated RNA, and seem to be linked to defects in nuclear export. Nucleolar aggresomes have been identified in non-neuronal cells, but prominent similarities with nuclear ubiquitin and/or ribonuclear foci detected in triplet and other repeat disease pathologies are revealed here, creating a common interest between research in cancer and neurodegeneration.",
keywords = "Aggresome, Cancer, Inclusion diseases, Neurodegeneration, Nucleolus, Ubiquitin proteasome system",
author = "Leena Latonen",
year = "2011",
month = "5",
doi = "10.1002/bies.201100008",
language = "English",
volume = "33",
pages = "386--395",
journal = "BioEssays",
issn = "0265-9247",
publisher = "Wiley-VCH Verlag",
number = "5",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress

AU - Latonen, Leena

PY - 2011/5

Y1 - 2011/5

N2 - The nucleolus may represent a key stress response organelle in the nucleus following proteotoxic stress by serving as a platform for protein aggregates. Aggregation of proteins often results from insufficient protein degradation by the ubiquitin-proteasome system (UPS), occurring in inclusion diseases, upon treatment by proteasome inhibitors (PIs) or due to various forms of stress. As the nucleolar inclusions resemble cytoplasmic aggresomes in gathering ubiquitin and numerous UPS components and targets, including cancer-related transcription factors and cell cycle regulators (e.g. p53 and cyclin D) and proteins involved in neurodegenerative diseases (e.g. ataxin-1, Malin), these organelles are termed herein as nucleolar aggresomes. These nucleolar aggresomes contain polyadenylated RNA, and seem to be linked to defects in nuclear export. Nucleolar aggresomes have been identified in non-neuronal cells, but prominent similarities with nuclear ubiquitin and/or ribonuclear foci detected in triplet and other repeat disease pathologies are revealed here, creating a common interest between research in cancer and neurodegeneration.

AB - The nucleolus may represent a key stress response organelle in the nucleus following proteotoxic stress by serving as a platform for protein aggregates. Aggregation of proteins often results from insufficient protein degradation by the ubiquitin-proteasome system (UPS), occurring in inclusion diseases, upon treatment by proteasome inhibitors (PIs) or due to various forms of stress. As the nucleolar inclusions resemble cytoplasmic aggresomes in gathering ubiquitin and numerous UPS components and targets, including cancer-related transcription factors and cell cycle regulators (e.g. p53 and cyclin D) and proteins involved in neurodegenerative diseases (e.g. ataxin-1, Malin), these organelles are termed herein as nucleolar aggresomes. These nucleolar aggresomes contain polyadenylated RNA, and seem to be linked to defects in nuclear export. Nucleolar aggresomes have been identified in non-neuronal cells, but prominent similarities with nuclear ubiquitin and/or ribonuclear foci detected in triplet and other repeat disease pathologies are revealed here, creating a common interest between research in cancer and neurodegeneration.

KW - Aggresome

KW - Cancer

KW - Inclusion diseases

KW - Neurodegeneration

KW - Nucleolus

KW - Ubiquitin proteasome system

UR - http://www.scopus.com/inward/record.url?scp=79954807086&partnerID=8YFLogxK

U2 - 10.1002/bies.201100008

DO - 10.1002/bies.201100008

M3 - Review Article

VL - 33

SP - 386

EP - 395

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 5

ER -