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TUTCRIS

On electrophysiological signal complexity during biological neuronal network development and maturation

Tutkimustuotosvertaisarvioitu

Yksityiskohdat

AlkuperäiskieliEnglanti
Otsikko2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
KustantajaIEEE
ISBN (elektroninen)978-1-5090-2809-2
DOI - pysyväislinkit
TilaJulkaistu - 15 heinäkuuta 2017
OKM-julkaisutyyppiA4 Artikkeli konferenssijulkaisussa
TapahtumaANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY -
Kesto: 1 tammikuuta 1900 → …

Conference

ConferenceANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY
Ajanjakso1/01/00 → …

Tiivistelmä

Developing neuronal populations are assumed to increase their synaptic interactions and generate synchronized activity, such as bursting, during maturation. These effects may arise from increasing interactions of neuronal populations and increasing simultaneous intra-population activity in developing networks. In this paper, we investigated the neuronal network activity and its complexity by means of self-similarity during neuronal network development. We studied the phenomena using computational neuronal network models and actual in vitro microelectrode array data measured from a developing neuronal network of dissociated mouse cortical neurons. To achieve this, we assessed the spiking and bursting characteristics of the networks, and computed the signal complexity with Sample Entropy. The results show that we can relate increasing simultaneous activity in a neuronal population with decreasing entropy, and track the network development and maturation using this. We can conclude that the complexity of neuronal network signals decreases during the maturation. This can emerge from the fact that as networks mature, they exhibit more synchro-nous activity, thus decreasing the complexity of its signaling. However, increasing the number of interacting populations has lesser effect on the signal complexity. The entropy based measure provides a tool to assess the complexity of the neuronal network activity, and can be useful in the assessment of developing networks or the effects of drugs and toxins on their functioning.

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