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Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films

Tutkimustuotosvertaisarvioitu

Standard

Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films. / Laurén, Patrick; Paukkonen, Heli; Lipiäinen, Tiina; Dong, Yujiao; Oksanen, Timo; Räikkönen, Heikki; Ehlers, Henrik; Laaksonen, Päivi; Yliperttula, Marjo; Laaksonen, Timo.

julkaisussa: Pharmaceutical Research, Vuosikerta 35, Nro 7, 145, 01.07.2018.

Tutkimustuotosvertaisarvioitu

Harvard

Laurén, P, Paukkonen, H, Lipiäinen, T, Dong, Y, Oksanen, T, Räikkönen, H, Ehlers, H, Laaksonen, P, Yliperttula, M & Laaksonen, T 2018, 'Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films', Pharmaceutical Research, Vuosikerta. 35, Nro 7, 145. https://doi.org/10.1007/s11095-018-2428-z

APA

Laurén, P., Paukkonen, H., Lipiäinen, T., Dong, Y., Oksanen, T., Räikkönen, H., ... Laaksonen, T. (2018). Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films. Pharmaceutical Research, 35(7), [145]. https://doi.org/10.1007/s11095-018-2428-z

Vancouver

Laurén P, Paukkonen H, Lipiäinen T, Dong Y, Oksanen T, Räikkönen H et al. Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films. Pharmaceutical Research. 2018 heinä 1;35(7). 145. https://doi.org/10.1007/s11095-018-2428-z

Author

Laurén, Patrick ; Paukkonen, Heli ; Lipiäinen, Tiina ; Dong, Yujiao ; Oksanen, Timo ; Räikkönen, Heikki ; Ehlers, Henrik ; Laaksonen, Päivi ; Yliperttula, Marjo ; Laaksonen, Timo. / Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films. Julkaisussa: Pharmaceutical Research. 2018 ; Vuosikerta 35, Nro 7.

Bibtex - Lataa

@article{2674c23ff66d4b73be3936bf09011354,
title = "Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films",
abstract = "Purpose: Bioadhesion is an important property of biological membranes, that can be utilized in pharmaceutical and biomedical applications. In this study, we have fabricated mucoadhesive drug releasing films with bio-based, non-toxic and biodegradable polymers that do not require chemical modifications. Methods: Nanofibrillar cellulose and anionic type nanofibrillar cellulose were used as film forming materials with known mucoadhesive components mucin, pectin and chitosan as functional bioadhesion enhancers. Different polymer combinations were investigated to study the adhesiveness, solid state characteristics, film morphology, swelling, mechanical properties, drug release with the model compound metronidazole and in vitro cytotoxicity using TR146 cells to model buccal epithelium. Results: SEM revealed lamellar structures within the films, which had a thickness ranging 40–240 μm depending on the film polymer composition. All bioadhesive components were non-toxic and showed high adhesiveness. Rapid drug release was observed, as 60–80{\%} of the total amount of metronidazole was released in 30 min depending on the film formulation. Conclusions: The liquid molding used was a straightforward and simple method to produce drug releasing highly mucoadhesive films, which could be utilized in treating local oral diseases, such as periodontitis. All materials used were natural biodegradable polymers from renewable sources, which are generally regarded as safe.",
keywords = "bioadhesion, drug release, mucoadhesion, nanofibrillar cellulose, TR146",
author = "Patrick Laur{\'e}n and Heli Paukkonen and Tiina Lipi{\"a}inen and Yujiao Dong and Timo Oksanen and Heikki R{\"a}ikk{\"o}nen and Henrik Ehlers and P{\"a}ivi Laaksonen and Marjo Yliperttula and Timo Laaksonen",
year = "2018",
month = "7",
day = "1",
doi = "10.1007/s11095-018-2428-z",
language = "English",
volume = "35",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "American Association of Pharmaceutical Scientists",
number = "7",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films

AU - Laurén, Patrick

AU - Paukkonen, Heli

AU - Lipiäinen, Tiina

AU - Dong, Yujiao

AU - Oksanen, Timo

AU - Räikkönen, Heikki

AU - Ehlers, Henrik

AU - Laaksonen, Päivi

AU - Yliperttula, Marjo

AU - Laaksonen, Timo

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Purpose: Bioadhesion is an important property of biological membranes, that can be utilized in pharmaceutical and biomedical applications. In this study, we have fabricated mucoadhesive drug releasing films with bio-based, non-toxic and biodegradable polymers that do not require chemical modifications. Methods: Nanofibrillar cellulose and anionic type nanofibrillar cellulose were used as film forming materials with known mucoadhesive components mucin, pectin and chitosan as functional bioadhesion enhancers. Different polymer combinations were investigated to study the adhesiveness, solid state characteristics, film morphology, swelling, mechanical properties, drug release with the model compound metronidazole and in vitro cytotoxicity using TR146 cells to model buccal epithelium. Results: SEM revealed lamellar structures within the films, which had a thickness ranging 40–240 μm depending on the film polymer composition. All bioadhesive components were non-toxic and showed high adhesiveness. Rapid drug release was observed, as 60–80% of the total amount of metronidazole was released in 30 min depending on the film formulation. Conclusions: The liquid molding used was a straightforward and simple method to produce drug releasing highly mucoadhesive films, which could be utilized in treating local oral diseases, such as periodontitis. All materials used were natural biodegradable polymers from renewable sources, which are generally regarded as safe.

AB - Purpose: Bioadhesion is an important property of biological membranes, that can be utilized in pharmaceutical and biomedical applications. In this study, we have fabricated mucoadhesive drug releasing films with bio-based, non-toxic and biodegradable polymers that do not require chemical modifications. Methods: Nanofibrillar cellulose and anionic type nanofibrillar cellulose were used as film forming materials with known mucoadhesive components mucin, pectin and chitosan as functional bioadhesion enhancers. Different polymer combinations were investigated to study the adhesiveness, solid state characteristics, film morphology, swelling, mechanical properties, drug release with the model compound metronidazole and in vitro cytotoxicity using TR146 cells to model buccal epithelium. Results: SEM revealed lamellar structures within the films, which had a thickness ranging 40–240 μm depending on the film polymer composition. All bioadhesive components were non-toxic and showed high adhesiveness. Rapid drug release was observed, as 60–80% of the total amount of metronidazole was released in 30 min depending on the film formulation. Conclusions: The liquid molding used was a straightforward and simple method to produce drug releasing highly mucoadhesive films, which could be utilized in treating local oral diseases, such as periodontitis. All materials used were natural biodegradable polymers from renewable sources, which are generally regarded as safe.

KW - bioadhesion

KW - drug release

KW - mucoadhesion

KW - nanofibrillar cellulose

KW - TR146

U2 - 10.1007/s11095-018-2428-z

DO - 10.1007/s11095-018-2428-z

M3 - Article

VL - 35

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 7

M1 - 145

ER -