TUTCRIS - Tampereen teknillinen yliopisto

TUTCRIS

Polymer looping is controlled by macromolecular crowding, spatial confinement, and chain stiffness

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Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut202-206
Sivumäärä5
JulkaisuACS Macro Letters
Vuosikerta4
Numero2
DOI - pysyväislinkit
TilaJulkaistu - 17 helmikuuta 2015
OKM-julkaisutyyppiA1 Alkuperäisartikkeli

Tiivistelmä

We study by extensive computer simulations the looping characteristics of linear polymers with varying persistence length inside a spherical cavity in the presence of macromolecular crowding. For stiff chains, the looping probability and looping time reveal wildly oscillating patterns as functions of the chain length. The effects of crowding differ dramatically for flexible versus stiff polymers. While for flexible chains the looping kinetics is slowed down by the crowders, for stiffer chains the kinetics turns out to be either decreased or facilitated, depending on the polymer length. For severe confinement, the looping kinetics may become strongly facilitated by crowding. Our findings are of broad impact for DNA looping in the crowded and compartmentalized interior of living biological cells.

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