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Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks

Tutkimustuotosvertaisarvioitu

Standard

Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials : Inflammation and DNA strand breaks. / Hadrup, Niels; Saber, Anne T.; Kyjovska, Zdenka O.; Jacobsen, Nicklas R.; Vippola, Minnamari; Sarlin, Essi; Ding, Yaobo; Schmid, Otmar; Wallin, Håkan; Jensen, Keld A.; Vogel, Ulla.

julkaisussa: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, Vuosikerta 74, 103303, 02.2020.

Tutkimustuotosvertaisarvioitu

Harvard

Hadrup, N, Saber, AT, Kyjovska, ZO, Jacobsen, NR, Vippola, M, Sarlin, E, Ding, Y, Schmid, O, Wallin, H, Jensen, KA & Vogel, U 2020, 'Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks', ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, Vuosikerta. 74, 103303. https://doi.org/10.1016/j.etap.2019.103303

APA

Hadrup, N., Saber, A. T., Kyjovska, Z. O., Jacobsen, N. R., Vippola, M., Sarlin, E., ... Vogel, U. (2020). Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 74, [103303]. https://doi.org/10.1016/j.etap.2019.103303

Vancouver

Hadrup N, Saber AT, Kyjovska ZO, Jacobsen NR, Vippola M, Sarlin E et al. Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. 2020 helmi;74. 103303. https://doi.org/10.1016/j.etap.2019.103303

Author

Hadrup, Niels ; Saber, Anne T. ; Kyjovska, Zdenka O. ; Jacobsen, Nicklas R. ; Vippola, Minnamari ; Sarlin, Essi ; Ding, Yaobo ; Schmid, Otmar ; Wallin, Håkan ; Jensen, Keld A. ; Vogel, Ulla. / Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials : Inflammation and DNA strand breaks. Julkaisussa: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. 2020 ; Vuosikerta 74.

Bibtex - Lataa

@article{9046eb293b9e41279940cd84fecb8a22,
title = "Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks",
abstract = "Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 μg by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation – neutrophil influx into bronchoalveolar lavage (BAL) fluid – occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials.",
keywords = "Iron, Metal oxides, Nanomaterial, Nickel, Pulmonary, Zinc",
author = "Niels Hadrup and Saber, {Anne T.} and Kyjovska, {Zdenka O.} and Jacobsen, {Nicklas R.} and Minnamari Vippola and Essi Sarlin and Yaobo Ding and Otmar Schmid and H{\aa}kan Wallin and Jensen, {Keld A.} and Ulla Vogel",
year = "2020",
month = "2",
doi = "10.1016/j.etap.2019.103303",
language = "English",
volume = "74",
journal = "ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY",
issn = "1382-6689",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials

T2 - Inflammation and DNA strand breaks

AU - Hadrup, Niels

AU - Saber, Anne T.

AU - Kyjovska, Zdenka O.

AU - Jacobsen, Nicklas R.

AU - Vippola, Minnamari

AU - Sarlin, Essi

AU - Ding, Yaobo

AU - Schmid, Otmar

AU - Wallin, Håkan

AU - Jensen, Keld A.

AU - Vogel, Ulla

PY - 2020/2

Y1 - 2020/2

N2 - Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 μg by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation – neutrophil influx into bronchoalveolar lavage (BAL) fluid – occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials.

AB - Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 μg by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation – neutrophil influx into bronchoalveolar lavage (BAL) fluid – occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials.

KW - Iron

KW - Metal oxides

KW - Nanomaterial

KW - Nickel

KW - Pulmonary

KW - Zinc

U2 - 10.1016/j.etap.2019.103303

DO - 10.1016/j.etap.2019.103303

M3 - Article

VL - 74

JO - ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

JF - ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

SN - 1382-6689

M1 - 103303

ER -