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Real-time observation of bacterial gene expression noise

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Real-time observation of bacterial gene expression noise. / Anufrieva, Olga; Sala, Adrien; Yli-Harja, Olli; Kandhavelu, Meenakshisundaram.

julkaisussa: Nano Communication Networks, Vuosikerta 8, 06.2016, s. 68-75.

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Anufrieva, O, Sala, A, Yli-Harja, O & Kandhavelu, M 2016, 'Real-time observation of bacterial gene expression noise', Nano Communication Networks, Vuosikerta. 8, Sivut 68-75. https://doi.org/10.1016/j.nancom.2016.03.001

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Anufrieva, Olga ; Sala, Adrien ; Yli-Harja, Olli ; Kandhavelu, Meenakshisundaram. / Real-time observation of bacterial gene expression noise. Julkaisussa: Nano Communication Networks. 2016 ; Vuosikerta 8. Sivut 68-75.

Bibtex - Lataa

@article{95c29cbf4adc4c6484c3a163245d8849,
title = "Real-time observation of bacterial gene expression noise",
abstract = "The mRNA variability in the single cells attributes to random periods of transcription bursts. The cell cycle possesses a global role in affecting transcriptional output. By expressing this process as a communication system at the nanoscale, this transcription output often accounts for the gene expression noise, and this quantifies the promoter activity. However, current stochastic models ignore the fact that gene expression noise is affected not only by the cell cycle and promoter activity, but, also, by the time during which new mRNAs are produced. Here we show that noise from the lac promoter in E.coli is dominated by intrinsic and extrinsic noises in slow and fast dividing cells, respectively. Such domination of the noise components in phases with different generation times is achieved through distinct and combinatorial interactions between the upstream/downstream regulatory elements. These mechanisms serve as an adaptive strategy for increasing population homogeneity under changing environments.",
keywords = "Bursty mRNA production, Cell cycle, Gene expression, lac promoter, Noise components",
author = "Olga Anufrieva and Adrien Sala and Olli Yli-Harja and Meenakshisundaram Kandhavelu",
year = "2016",
month = "6",
doi = "10.1016/j.nancom.2016.03.001",
language = "English",
volume = "8",
pages = "68--75",
journal = "Nano Communication Networks",
issn = "1878-7789",
publisher = "Elsevier Science B.V.",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Real-time observation of bacterial gene expression noise

AU - Anufrieva, Olga

AU - Sala, Adrien

AU - Yli-Harja, Olli

AU - Kandhavelu, Meenakshisundaram

PY - 2016/6

Y1 - 2016/6

N2 - The mRNA variability in the single cells attributes to random periods of transcription bursts. The cell cycle possesses a global role in affecting transcriptional output. By expressing this process as a communication system at the nanoscale, this transcription output often accounts for the gene expression noise, and this quantifies the promoter activity. However, current stochastic models ignore the fact that gene expression noise is affected not only by the cell cycle and promoter activity, but, also, by the time during which new mRNAs are produced. Here we show that noise from the lac promoter in E.coli is dominated by intrinsic and extrinsic noises in slow and fast dividing cells, respectively. Such domination of the noise components in phases with different generation times is achieved through distinct and combinatorial interactions between the upstream/downstream regulatory elements. These mechanisms serve as an adaptive strategy for increasing population homogeneity under changing environments.

AB - The mRNA variability in the single cells attributes to random periods of transcription bursts. The cell cycle possesses a global role in affecting transcriptional output. By expressing this process as a communication system at the nanoscale, this transcription output often accounts for the gene expression noise, and this quantifies the promoter activity. However, current stochastic models ignore the fact that gene expression noise is affected not only by the cell cycle and promoter activity, but, also, by the time during which new mRNAs are produced. Here we show that noise from the lac promoter in E.coli is dominated by intrinsic and extrinsic noises in slow and fast dividing cells, respectively. Such domination of the noise components in phases with different generation times is achieved through distinct and combinatorial interactions between the upstream/downstream regulatory elements. These mechanisms serve as an adaptive strategy for increasing population homogeneity under changing environments.

KW - Bursty mRNA production

KW - Cell cycle

KW - Gene expression

KW - lac promoter

KW - Noise components

U2 - 10.1016/j.nancom.2016.03.001

DO - 10.1016/j.nancom.2016.03.001

M3 - Article

VL - 8

SP - 68

EP - 75

JO - Nano Communication Networks

JF - Nano Communication Networks

SN - 1878-7789

ER -