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Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes

Tutkimustuotosvertaisarvioitu

Yksityiskohdat

AlkuperäiskieliEnglanti
OtsikkoComputing in Cardiology 2017
Sivumäärä4
Vuosikerta44
DOI - pysyväislinkit
TilaJulkaistu - 2017
OKM-julkaisutyyppiA4 Artikkeli konferenssijulkaisussa
TapahtumaCOMPUTING IN CARDIOLOGY CONFERENCE -
Kesto: 1 tammikuuta 1900 → …

Julkaisusarja

NimiComputing in Cardiology
ISSN (painettu)2325-8861

Conference

ConferenceCOMPUTING IN CARDIOLOGY CONFERENCE
Ajanjakso1/01/00 → …

Tiivistelmä

A healthy heart exhibits fractal, i.e., long-range correlated fluctuations in heart rate variability (HRV). It is recently shown that fractal dynamics is also an intrinsic feature of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). In this study, we investigate short- and long-range correlations in beat rate variability (BRV) of hiPSC-CMs, obtained from a healthy subject and symptomatic and asymptomatic long QT syndrome patients. It is shown that it is important to distinguish correlation properties in short and long time scales, as the scaling exponents are significantly different and also behave differently in the acute exposure to pharmacological compounds that modulate β1-adrenoreceptors and cardiac ion channel generating delayed, outwardly rectifying K+ current (IKs). While long-range scaling is sensitive to the drug exposure, short-range scaling is barely affected.

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