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Solid-phase bromination and Suzuki coupling of 2-carboxyindoles

Tutkimustuotosvertaisarvioitu

Standard

Solid-phase bromination and Suzuki coupling of 2-carboxyindoles. / Tois, J.; Franzén, R.; Aitio, O.; Laakso, I.; Huuskonen, J.; Taskinen, J.

julkaisussa: Combinatorial Chemistry and High Throughput Screening, Vuosikerta 4, Nro 6, 2001, s. 521-524.

Tutkimustuotosvertaisarvioitu

Harvard

Tois, J, Franzén, R, Aitio, O, Laakso, I, Huuskonen, J & Taskinen, J 2001, 'Solid-phase bromination and Suzuki coupling of 2-carboxyindoles', Combinatorial Chemistry and High Throughput Screening, Vuosikerta. 4, Nro 6, Sivut 521-524. https://doi.org/10.2174/1386207013330887

APA

Tois, J., Franzén, R., Aitio, O., Laakso, I., Huuskonen, J., & Taskinen, J. (2001). Solid-phase bromination and Suzuki coupling of 2-carboxyindoles. Combinatorial Chemistry and High Throughput Screening, 4(6), 521-524. https://doi.org/10.2174/1386207013330887

Vancouver

Tois J, Franzén R, Aitio O, Laakso I, Huuskonen J, Taskinen J. Solid-phase bromination and Suzuki coupling of 2-carboxyindoles. Combinatorial Chemistry and High Throughput Screening. 2001;4(6):521-524. https://doi.org/10.2174/1386207013330887

Author

Tois, J. ; Franzén, R. ; Aitio, O. ; Laakso, I. ; Huuskonen, J. ; Taskinen, J. / Solid-phase bromination and Suzuki coupling of 2-carboxyindoles. Julkaisussa: Combinatorial Chemistry and High Throughput Screening. 2001 ; Vuosikerta 4, Nro 6. Sivut 521-524.

Bibtex - Lataa

@article{42cfcb59d7544863ac00dfb52d92230c,
title = "Solid-phase bromination and Suzuki coupling of 2-carboxyindoles",
abstract = "As part of an ongoing lead discovery project we have developed a convenient method for the modification and substitution of indole moieties at the 3-position. Selective bromination of three different 2-carboxyindoles was followed by Suzuki cross-coupling with aryl and heteroaryl boronic acids on a Merrifield resin solid-phase. After column chromatography, yields of the 3- substituted indoles ranged from 42-98{\%}.",
author = "J. Tois and R. Franz{\'e}n and O. Aitio and I. Laakso and J. Huuskonen and J. Taskinen",
year = "2001",
doi = "10.2174/1386207013330887",
language = "English",
volume = "4",
pages = "521--524",
journal = "Combinatorial Chemistry and High Throughput Screening",
issn = "1386-2073",
publisher = "BENTHAM SCIENCE PUBL LTD",
number = "6",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Solid-phase bromination and Suzuki coupling of 2-carboxyindoles

AU - Tois, J.

AU - Franzén, R.

AU - Aitio, O.

AU - Laakso, I.

AU - Huuskonen, J.

AU - Taskinen, J.

PY - 2001

Y1 - 2001

N2 - As part of an ongoing lead discovery project we have developed a convenient method for the modification and substitution of indole moieties at the 3-position. Selective bromination of three different 2-carboxyindoles was followed by Suzuki cross-coupling with aryl and heteroaryl boronic acids on a Merrifield resin solid-phase. After column chromatography, yields of the 3- substituted indoles ranged from 42-98%.

AB - As part of an ongoing lead discovery project we have developed a convenient method for the modification and substitution of indole moieties at the 3-position. Selective bromination of three different 2-carboxyindoles was followed by Suzuki cross-coupling with aryl and heteroaryl boronic acids on a Merrifield resin solid-phase. After column chromatography, yields of the 3- substituted indoles ranged from 42-98%.

UR - http://www.scopus.com/inward/record.url?scp=0034861953&partnerID=8YFLogxK

U2 - 10.2174/1386207013330887

DO - 10.2174/1386207013330887

M3 - Article

VL - 4

SP - 521

EP - 524

JO - Combinatorial Chemistry and High Throughput Screening

JF - Combinatorial Chemistry and High Throughput Screening

SN - 1386-2073

IS - 6

ER -