TUTCRIS - Tampereen teknillinen yliopisto

TUTCRIS

Statistical inference and reverse engineering of gene regulatory networks from observational expression data

Tutkimustuotosvertaisarvioitu

Yksityiskohdat

AlkuperäiskieliEnglanti
ArtikkeliArticle 8
JulkaisuFrontiers in Genetics
Vuosikerta3
NumeroFEB
DOI - pysyväislinkit
TilaJulkaistu - 2012
OKM-julkaisutyyppiA1 Alkuperäisartikkeli

Tiivistelmä

In this paper, we present a systematic and conceptual overview of methods for inferring gene regulatory networks from observational gene expression data. Further, we discuss two classic approaches to infer causal structures and compare them with contemporary methods by providing a conceptual categorization thereof. We complement the above by surveying global and local evaluation measures for assessing the performance of inference algorithms.

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