TUTCRIS - Tampereen teknillinen yliopisto

TUTCRIS

The concurrent use of aromatase inhibitors and radiotherapy induces echocardiographic changes in patients with breast cancer

Tutkimustuotosvertaisarvioitu

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut1559-1566
Sivumäärä8
JulkaisuAnticancer Research
Vuosikerta35
Numero3
TilaJulkaistu - 1 maaliskuuta 2015
OKM-julkaisutyyppiA1 Alkuperäisartikkeli

Tiivistelmä

Aim: Adjuvant radiotherapy (RT) for left-sided breast cancer has a negative impact on cardiac health. The concurrent use of aromatase inhibitors (AIs) during RT was found to increase the anticancer efficacy of radiation in preclinical models. We evaluated whether the acute effects of RT on cardiac functions are augmented by the concurrent use of AIs. Patients and Methods: Sixty patients with early-stage left-sided breast cancer underwent a 2D echocardiography, electrocardiogram and cardiac biomarker measurements before and after adjuvant breast RT. Data were analyzed in two groups according to AI use. Results: We observed a significant (p

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