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Treatments with sodium selenate or doxycycline offset diabetes-induced perturbations of thioredoxin-1 levels and antioxidant capacity

Tutkimustuotosvertaisarvioitu

Standard

Treatments with sodium selenate or doxycycline offset diabetes-induced perturbations of thioredoxin-1 levels and antioxidant capacity. / Atalay, Mustafa; Bilginoglu, Ayca; Kokkola, Tarja; Oksala, Niku; Turan, Belma.

julkaisussa: MOLECULAR AND CELLULAR BIOCHEMISTRY, Vuosikerta 351, Nro 1-2, 05.2011, s. 125-131.

Tutkimustuotosvertaisarvioitu

Harvard

Atalay, M, Bilginoglu, A, Kokkola, T, Oksala, N & Turan, B 2011, 'Treatments with sodium selenate or doxycycline offset diabetes-induced perturbations of thioredoxin-1 levels and antioxidant capacity', MOLECULAR AND CELLULAR BIOCHEMISTRY, Vuosikerta. 351, Nro 1-2, Sivut 125-131. https://doi.org/10.1007/s11010-011-0719-3

APA

Atalay, M., Bilginoglu, A., Kokkola, T., Oksala, N., & Turan, B. (2011). Treatments with sodium selenate or doxycycline offset diabetes-induced perturbations of thioredoxin-1 levels and antioxidant capacity. MOLECULAR AND CELLULAR BIOCHEMISTRY, 351(1-2), 125-131. https://doi.org/10.1007/s11010-011-0719-3

Vancouver

Atalay M, Bilginoglu A, Kokkola T, Oksala N, Turan B. Treatments with sodium selenate or doxycycline offset diabetes-induced perturbations of thioredoxin-1 levels and antioxidant capacity. MOLECULAR AND CELLULAR BIOCHEMISTRY. 2011 touko;351(1-2):125-131. https://doi.org/10.1007/s11010-011-0719-3

Author

Atalay, Mustafa ; Bilginoglu, Ayca ; Kokkola, Tarja ; Oksala, Niku ; Turan, Belma. / Treatments with sodium selenate or doxycycline offset diabetes-induced perturbations of thioredoxin-1 levels and antioxidant capacity. Julkaisussa: MOLECULAR AND CELLULAR BIOCHEMISTRY. 2011 ; Vuosikerta 351, Nro 1-2. Sivut 125-131.

Bibtex - Lataa

@article{46b1425d046e4d18bc357ac87a4e34ad,
title = "Treatments with sodium selenate or doxycycline offset diabetes-induced perturbations of thioredoxin-1 levels and antioxidant capacity",
abstract = "Diabetes is associated with increased oxidative stress and impaired antioxidant defenses. Thioredoxin-1 (TRX-1) is a cytosolic thiol antioxidant and redox-active protein which plays a vital role in the maintenance of reduced intracellular redox state. In this study, the authors examined whether 4-week treatments with sodium selenate and doxycycline-a metalloproteinase-2 inhibitor which also has antioxidant-like effects-offset perturbations in oxidative stress and antioxidant protection in rat liver and skeletal muscle in streptozotocin-induced diabetes (SID) model. Experimental diabetes decreased TRX-1 levels in skeletal muscle and liver. On the other hand, SID increased oxidative stress marker protein carbonyl levels and decreased oxygen radical absorbance capacity (ORAC), an indicator of antioxidant capacity, in liver. A 4-week treatment of sodium selenate to diabetic rats decreased blood glucose levels moderately, while doxycycline treatment caused a reduction in weight loss of diabetic rats. Both doxycycline and sodium selenate prevented diabetes-induced decrease of TRX-1 levels in skeletal muscle, whereas only doxyxycline was effectively preventing diabetes-induced decrease of TRX-1 in liver. Furthermore, both treatments prevented diabetes-induced altered levels of protein carbonyls and ORAC in liver, and restored free and total protein thiol levels in both skeletal muscle and liver. In conclusion, the data of this study provides further evidence that sodium selenate and doxycycline treatments may control oxidative stress and improve antioxidant defense in diabetes.",
keywords = "Liver, Oxidative stress, Oxygen radical absorbance capacity, Protein carbonyls, Protein thiols, Skeletal muscle, Thioredoxin-1",
author = "Mustafa Atalay and Ayca Bilginoglu and Tarja Kokkola and Niku Oksala and Belma Turan",
year = "2011",
month = "5",
doi = "10.1007/s11010-011-0719-3",
language = "English",
volume = "351",
pages = "125--131",
journal = "MOLECULAR AND CELLULAR BIOCHEMISTRY",
issn = "0300-8177",
publisher = "Springer Verlag",
number = "1-2",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Treatments with sodium selenate or doxycycline offset diabetes-induced perturbations of thioredoxin-1 levels and antioxidant capacity

AU - Atalay, Mustafa

AU - Bilginoglu, Ayca

AU - Kokkola, Tarja

AU - Oksala, Niku

AU - Turan, Belma

PY - 2011/5

Y1 - 2011/5

N2 - Diabetes is associated with increased oxidative stress and impaired antioxidant defenses. Thioredoxin-1 (TRX-1) is a cytosolic thiol antioxidant and redox-active protein which plays a vital role in the maintenance of reduced intracellular redox state. In this study, the authors examined whether 4-week treatments with sodium selenate and doxycycline-a metalloproteinase-2 inhibitor which also has antioxidant-like effects-offset perturbations in oxidative stress and antioxidant protection in rat liver and skeletal muscle in streptozotocin-induced diabetes (SID) model. Experimental diabetes decreased TRX-1 levels in skeletal muscle and liver. On the other hand, SID increased oxidative stress marker protein carbonyl levels and decreased oxygen radical absorbance capacity (ORAC), an indicator of antioxidant capacity, in liver. A 4-week treatment of sodium selenate to diabetic rats decreased blood glucose levels moderately, while doxycycline treatment caused a reduction in weight loss of diabetic rats. Both doxycycline and sodium selenate prevented diabetes-induced decrease of TRX-1 levels in skeletal muscle, whereas only doxyxycline was effectively preventing diabetes-induced decrease of TRX-1 in liver. Furthermore, both treatments prevented diabetes-induced altered levels of protein carbonyls and ORAC in liver, and restored free and total protein thiol levels in both skeletal muscle and liver. In conclusion, the data of this study provides further evidence that sodium selenate and doxycycline treatments may control oxidative stress and improve antioxidant defense in diabetes.

AB - Diabetes is associated with increased oxidative stress and impaired antioxidant defenses. Thioredoxin-1 (TRX-1) is a cytosolic thiol antioxidant and redox-active protein which plays a vital role in the maintenance of reduced intracellular redox state. In this study, the authors examined whether 4-week treatments with sodium selenate and doxycycline-a metalloproteinase-2 inhibitor which also has antioxidant-like effects-offset perturbations in oxidative stress and antioxidant protection in rat liver and skeletal muscle in streptozotocin-induced diabetes (SID) model. Experimental diabetes decreased TRX-1 levels in skeletal muscle and liver. On the other hand, SID increased oxidative stress marker protein carbonyl levels and decreased oxygen radical absorbance capacity (ORAC), an indicator of antioxidant capacity, in liver. A 4-week treatment of sodium selenate to diabetic rats decreased blood glucose levels moderately, while doxycycline treatment caused a reduction in weight loss of diabetic rats. Both doxycycline and sodium selenate prevented diabetes-induced decrease of TRX-1 levels in skeletal muscle, whereas only doxyxycline was effectively preventing diabetes-induced decrease of TRX-1 in liver. Furthermore, both treatments prevented diabetes-induced altered levels of protein carbonyls and ORAC in liver, and restored free and total protein thiol levels in both skeletal muscle and liver. In conclusion, the data of this study provides further evidence that sodium selenate and doxycycline treatments may control oxidative stress and improve antioxidant defense in diabetes.

KW - Liver

KW - Oxidative stress

KW - Oxygen radical absorbance capacity

KW - Protein carbonyls

KW - Protein thiols

KW - Skeletal muscle

KW - Thioredoxin-1

UR - http://www.scopus.com/inward/record.url?scp=79953687940&partnerID=8YFLogxK

U2 - 10.1007/s11010-011-0719-3

DO - 10.1007/s11010-011-0719-3

M3 - Article

VL - 351

SP - 125

EP - 131

JO - MOLECULAR AND CELLULAR BIOCHEMISTRY

JF - MOLECULAR AND CELLULAR BIOCHEMISTRY

SN - 0300-8177

IS - 1-2

ER -