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Uniform and electrically conductive biopolymer-doped polypyrrole coating for fibrous PLA

Tutkimustuotosvertaisarvioitu

Standard

Uniform and electrically conductive biopolymer-doped polypyrrole coating for fibrous PLA. / Hiltunen, M.; Pelto, J.; Ellä, V.; Kellomäki, M.

julkaisussa: Journal of Biomedical Materials Research. Part B: Applied Biomaterials, Vuosikerta 104, Nro 8, 2016, s. 1721–1729.

Tutkimustuotosvertaisarvioitu

Harvard

Hiltunen, M, Pelto, J, Ellä, V & Kellomäki, M 2016, 'Uniform and electrically conductive biopolymer-doped polypyrrole coating for fibrous PLA', Journal of Biomedical Materials Research. Part B: Applied Biomaterials, Vuosikerta. 104, Nro 8, Sivut 1721–1729. https://doi.org/10.1002/jbm.b.33514

APA

Hiltunen, M., Pelto, J., Ellä, V., & Kellomäki, M. (2016). Uniform and electrically conductive biopolymer-doped polypyrrole coating for fibrous PLA. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 104(8), 1721–1729. https://doi.org/10.1002/jbm.b.33514

Vancouver

Hiltunen M, Pelto J, Ellä V, Kellomäki M. Uniform and electrically conductive biopolymer-doped polypyrrole coating for fibrous PLA. Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 2016;104(8):1721–1729. https://doi.org/10.1002/jbm.b.33514

Author

Hiltunen, M. ; Pelto, J. ; Ellä, V. ; Kellomäki, M. / Uniform and electrically conductive biopolymer-doped polypyrrole coating for fibrous PLA. Julkaisussa: Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 2016 ; Vuosikerta 104, Nro 8. Sivut 1721–1729.

Bibtex - Lataa

@article{0028f836dea340a8a4c6cfe9bfd9fb5a,
title = "Uniform and electrically conductive biopolymer-doped polypyrrole coating for fibrous PLA",
abstract = "Three-dimensional, fibrous scaffolds can be easily fabricated from polylactide (PLA) using melt spinning and textile techniques. However, the surface properties of PLA scaffolds are not ideal for tissue engineering purposes. Furthermore, electrically conducting scaffolds are required to deliver electrical stimulation to cells. In this study, uniform, electrically conducting polypyrrole (PPy) coatings were fabricated on biodegradable PLA fibers. Biopolymer dopants-hyaluronic acid (HA) and chondroitin sulfate (CS)-were compared, and a PPy/CS composition was analyzed further. The effect of the oxidative polymerization conditions on the PLA fibers and CS counterion was studied. Furthermore, the initial molecular weight of CS and its degree of polymerization were determined. Our experiments showed that the molecular weight of CS decreases under oxidizing conditions but that the decay is not significant with the short polymerization process we used. The coating process was transferred to nonwoven PLA fabrics, and the stability of PPy/CS coating was studied during in vitro incubation in phosphate buffer solution at physiological temperature. The conductivity and surface roughness of the coating decayed during the 20-day incubation. The mechanical strength, however, remained at the initial level. Thus, the fabricated structures are suitable for short-term electrical stimulation adequate to promote cell functions in specific cases.",
keywords = "Coating(s), Scaffolds, Stability, Surface characterization, Tissue engineering",
author = "M. Hiltunen and J. Pelto and V. Ell{\"a} and M. Kellom{\"a}ki",
note = "EXT={"}Pelto, J.{"}",
year = "2016",
doi = "10.1002/jbm.b.33514",
language = "English",
volume = "104",
pages = "1721–1729",
journal = "Journal of Biomedical Materials Research. Part B: Applied Biomaterials",
issn = "1552-4973",
publisher = "Wiley",
number = "8",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Uniform and electrically conductive biopolymer-doped polypyrrole coating for fibrous PLA

AU - Hiltunen, M.

AU - Pelto, J.

AU - Ellä, V.

AU - Kellomäki, M.

N1 - EXT="Pelto, J."

PY - 2016

Y1 - 2016

N2 - Three-dimensional, fibrous scaffolds can be easily fabricated from polylactide (PLA) using melt spinning and textile techniques. However, the surface properties of PLA scaffolds are not ideal for tissue engineering purposes. Furthermore, electrically conducting scaffolds are required to deliver electrical stimulation to cells. In this study, uniform, electrically conducting polypyrrole (PPy) coatings were fabricated on biodegradable PLA fibers. Biopolymer dopants-hyaluronic acid (HA) and chondroitin sulfate (CS)-were compared, and a PPy/CS composition was analyzed further. The effect of the oxidative polymerization conditions on the PLA fibers and CS counterion was studied. Furthermore, the initial molecular weight of CS and its degree of polymerization were determined. Our experiments showed that the molecular weight of CS decreases under oxidizing conditions but that the decay is not significant with the short polymerization process we used. The coating process was transferred to nonwoven PLA fabrics, and the stability of PPy/CS coating was studied during in vitro incubation in phosphate buffer solution at physiological temperature. The conductivity and surface roughness of the coating decayed during the 20-day incubation. The mechanical strength, however, remained at the initial level. Thus, the fabricated structures are suitable for short-term electrical stimulation adequate to promote cell functions in specific cases.

AB - Three-dimensional, fibrous scaffolds can be easily fabricated from polylactide (PLA) using melt spinning and textile techniques. However, the surface properties of PLA scaffolds are not ideal for tissue engineering purposes. Furthermore, electrically conducting scaffolds are required to deliver electrical stimulation to cells. In this study, uniform, electrically conducting polypyrrole (PPy) coatings were fabricated on biodegradable PLA fibers. Biopolymer dopants-hyaluronic acid (HA) and chondroitin sulfate (CS)-were compared, and a PPy/CS composition was analyzed further. The effect of the oxidative polymerization conditions on the PLA fibers and CS counterion was studied. Furthermore, the initial molecular weight of CS and its degree of polymerization were determined. Our experiments showed that the molecular weight of CS decreases under oxidizing conditions but that the decay is not significant with the short polymerization process we used. The coating process was transferred to nonwoven PLA fabrics, and the stability of PPy/CS coating was studied during in vitro incubation in phosphate buffer solution at physiological temperature. The conductivity and surface roughness of the coating decayed during the 20-day incubation. The mechanical strength, however, remained at the initial level. Thus, the fabricated structures are suitable for short-term electrical stimulation adequate to promote cell functions in specific cases.

KW - Coating(s)

KW - Scaffolds

KW - Stability

KW - Surface characterization

KW - Tissue engineering

U2 - 10.1002/jbm.b.33514

DO - 10.1002/jbm.b.33514

M3 - Article

VL - 104

SP - 1721

EP - 1729

JO - Journal of Biomedical Materials Research. Part B: Applied Biomaterials

JF - Journal of Biomedical Materials Research. Part B: Applied Biomaterials

SN - 1552-4973

IS - 8

ER -