TUTCRIS - Tampereen teknillinen yliopisto

TUTCRIS

White matter lesions are associated with hospital admissions because of hip-fractures and trauma after ischemic stroke

Tutkimustuotosvertaisarvioitu

Standard

White matter lesions are associated with hospital admissions because of hip-fractures and trauma after ischemic stroke. / Sibolt, Gerli; Curtze, Sami; Melkas, Susanna; Pohjasvaara, Tarja; Kaste, Markku; Karhunen, Pekka J.; Oksala, Niku K J; Strandberg, Timo; Erkinjuntti, Timo.

julkaisussa: STROKE, Vuosikerta 45, Nro 10, 12.10.2014, s. 2948-2951.

Tutkimustuotosvertaisarvioitu

Harvard

Sibolt, G, Curtze, S, Melkas, S, Pohjasvaara, T, Kaste, M, Karhunen, PJ, Oksala, NKJ, Strandberg, T & Erkinjuntti, T 2014, 'White matter lesions are associated with hospital admissions because of hip-fractures and trauma after ischemic stroke', STROKE, Vuosikerta. 45, Nro 10, Sivut 2948-2951. https://doi.org/10.1161/STROKEAHA.114.006116

APA

Sibolt, G., Curtze, S., Melkas, S., Pohjasvaara, T., Kaste, M., Karhunen, P. J., ... Erkinjuntti, T. (2014). White matter lesions are associated with hospital admissions because of hip-fractures and trauma after ischemic stroke. STROKE, 45(10), 2948-2951. https://doi.org/10.1161/STROKEAHA.114.006116

Vancouver

Sibolt G, Curtze S, Melkas S, Pohjasvaara T, Kaste M, Karhunen PJ et al. White matter lesions are associated with hospital admissions because of hip-fractures and trauma after ischemic stroke. STROKE. 2014 loka 12;45(10):2948-2951. https://doi.org/10.1161/STROKEAHA.114.006116

Author

Sibolt, Gerli ; Curtze, Sami ; Melkas, Susanna ; Pohjasvaara, Tarja ; Kaste, Markku ; Karhunen, Pekka J. ; Oksala, Niku K J ; Strandberg, Timo ; Erkinjuntti, Timo. / White matter lesions are associated with hospital admissions because of hip-fractures and trauma after ischemic stroke. Julkaisussa: STROKE. 2014 ; Vuosikerta 45, Nro 10. Sivut 2948-2951.

Bibtex - Lataa

@article{750184d5d4f64901bfdbf92dd666406d,
title = "White matter lesions are associated with hospital admissions because of hip-fractures and trauma after ischemic stroke",
abstract = "BACKGROUND AND PURPOSE -: Cerebral white matter lesions (WMLs), a surrogate for cerebral small-vessel disease, have been shown to be associated with decreasing mobility, gait instability, and falls. The aim of this study was to investigate whether WMLs of the brain are associated with increased incidence of hospital admissions because of any trauma and hip-fractures in a cohort of patients with stroke. METHODS -: We included 383 consecutive patients aged 55 to 85 years with ischemic stroke admitted to the Helsinki University Central Hospital (The Stroke Aging Memory cohort) with a 12-year follow-up. National register data were reviewed for hip-fractures, other traumatic injuries, survival data, and causes of death. WMLs were rated using MRI and dichotomized as none to mild and moderate to severe. The data were analyzed using Kaplan-Meier plots (log-rank) and a complex Cox multivariable hazards models for multiple cases per subject to assess hazard ratios with their 95{\%} confidence intervals. RESULTS -: During the 12-year follow-up, there were more hip-fractures (13.5{\%} versus 6.5{\%}; log-rank, P=0.01) and more hospital admissions because of traumatic injury (22.2{\%} versus 16.7{\%}; log-rank, P=0.04) in the moderate-to-severe than in the none-to-mild WMLs group. In the complex samples, Cox multivariable model adjusting for age, sex, National Institutes of Health Stroke Scale, infarct size, and poststroke dementia, moderate-to-severe WMLs were associated with increased incidences of hospital admissions because of hip-fractures (hazard ratio, 3.98; 95{\%} confidence interval, 1.55-10.21) and traumatic injuries including hip-fractures (hazard ratio, 1.72; 95{\%} confidence interval, 1.03-2.87). CONCLUSIONS -: Patients with ischemic stroke and moderate-to-severe WMLs are at high risk, who experience serious traumatic injuries and especially hip-fractures requiring hospital treatment.",
keywords = "cerebral small vessel diseases, hip fractures, trauma",
author = "Gerli Sibolt and Sami Curtze and Susanna Melkas and Tarja Pohjasvaara and Markku Kaste and Karhunen, {Pekka J.} and Oksala, {Niku K J} and Timo Strandberg and Timo Erkinjuntti",
year = "2014",
month = "10",
day = "12",
doi = "10.1161/STROKEAHA.114.006116",
language = "English",
volume = "45",
pages = "2948--2951",
journal = "STROKE",
issn = "0039-2499",
publisher = "American Heart Association",
number = "10",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - White matter lesions are associated with hospital admissions because of hip-fractures and trauma after ischemic stroke

AU - Sibolt, Gerli

AU - Curtze, Sami

AU - Melkas, Susanna

AU - Pohjasvaara, Tarja

AU - Kaste, Markku

AU - Karhunen, Pekka J.

AU - Oksala, Niku K J

AU - Strandberg, Timo

AU - Erkinjuntti, Timo

PY - 2014/10/12

Y1 - 2014/10/12

N2 - BACKGROUND AND PURPOSE -: Cerebral white matter lesions (WMLs), a surrogate for cerebral small-vessel disease, have been shown to be associated with decreasing mobility, gait instability, and falls. The aim of this study was to investigate whether WMLs of the brain are associated with increased incidence of hospital admissions because of any trauma and hip-fractures in a cohort of patients with stroke. METHODS -: We included 383 consecutive patients aged 55 to 85 years with ischemic stroke admitted to the Helsinki University Central Hospital (The Stroke Aging Memory cohort) with a 12-year follow-up. National register data were reviewed for hip-fractures, other traumatic injuries, survival data, and causes of death. WMLs were rated using MRI and dichotomized as none to mild and moderate to severe. The data were analyzed using Kaplan-Meier plots (log-rank) and a complex Cox multivariable hazards models for multiple cases per subject to assess hazard ratios with their 95% confidence intervals. RESULTS -: During the 12-year follow-up, there were more hip-fractures (13.5% versus 6.5%; log-rank, P=0.01) and more hospital admissions because of traumatic injury (22.2% versus 16.7%; log-rank, P=0.04) in the moderate-to-severe than in the none-to-mild WMLs group. In the complex samples, Cox multivariable model adjusting for age, sex, National Institutes of Health Stroke Scale, infarct size, and poststroke dementia, moderate-to-severe WMLs were associated with increased incidences of hospital admissions because of hip-fractures (hazard ratio, 3.98; 95% confidence interval, 1.55-10.21) and traumatic injuries including hip-fractures (hazard ratio, 1.72; 95% confidence interval, 1.03-2.87). CONCLUSIONS -: Patients with ischemic stroke and moderate-to-severe WMLs are at high risk, who experience serious traumatic injuries and especially hip-fractures requiring hospital treatment.

AB - BACKGROUND AND PURPOSE -: Cerebral white matter lesions (WMLs), a surrogate for cerebral small-vessel disease, have been shown to be associated with decreasing mobility, gait instability, and falls. The aim of this study was to investigate whether WMLs of the brain are associated with increased incidence of hospital admissions because of any trauma and hip-fractures in a cohort of patients with stroke. METHODS -: We included 383 consecutive patients aged 55 to 85 years with ischemic stroke admitted to the Helsinki University Central Hospital (The Stroke Aging Memory cohort) with a 12-year follow-up. National register data were reviewed for hip-fractures, other traumatic injuries, survival data, and causes of death. WMLs were rated using MRI and dichotomized as none to mild and moderate to severe. The data were analyzed using Kaplan-Meier plots (log-rank) and a complex Cox multivariable hazards models for multiple cases per subject to assess hazard ratios with their 95% confidence intervals. RESULTS -: During the 12-year follow-up, there were more hip-fractures (13.5% versus 6.5%; log-rank, P=0.01) and more hospital admissions because of traumatic injury (22.2% versus 16.7%; log-rank, P=0.04) in the moderate-to-severe than in the none-to-mild WMLs group. In the complex samples, Cox multivariable model adjusting for age, sex, National Institutes of Health Stroke Scale, infarct size, and poststroke dementia, moderate-to-severe WMLs were associated with increased incidences of hospital admissions because of hip-fractures (hazard ratio, 3.98; 95% confidence interval, 1.55-10.21) and traumatic injuries including hip-fractures (hazard ratio, 1.72; 95% confidence interval, 1.03-2.87). CONCLUSIONS -: Patients with ischemic stroke and moderate-to-severe WMLs are at high risk, who experience serious traumatic injuries and especially hip-fractures requiring hospital treatment.

KW - cerebral small vessel diseases

KW - hip fractures

KW - trauma

UR - http://www.scopus.com/inward/record.url?scp=84922481602&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.114.006116

DO - 10.1161/STROKEAHA.114.006116

M3 - Article

VL - 45

SP - 2948

EP - 2951

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 10

ER -