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Who gets recruited in mild traumatic brain injury research?

Tutkimustuotosvertaisarvioitu

Standard

Who gets recruited in mild traumatic brain injury research? / Luoto, Teemu M.; Tenovuo, Olli; Kataja, Anneli; Brander, Antti; Öhman, Juha; Iverson, Grant L.

julkaisussa: Journal of Neurotrauma, Vuosikerta 30, Nro 1, 01.01.2013, s. 11-16.

Tutkimustuotosvertaisarvioitu

Harvard

Luoto, TM, Tenovuo, O, Kataja, A, Brander, A, Öhman, J & Iverson, GL 2013, 'Who gets recruited in mild traumatic brain injury research?', Journal of Neurotrauma, Vuosikerta. 30, Nro 1, Sivut 11-16. https://doi.org/10.1089/neu.2012.2611

APA

Luoto, T. M., Tenovuo, O., Kataja, A., Brander, A., Öhman, J., & Iverson, G. L. (2013). Who gets recruited in mild traumatic brain injury research? Journal of Neurotrauma, 30(1), 11-16. https://doi.org/10.1089/neu.2012.2611

Vancouver

Luoto TM, Tenovuo O, Kataja A, Brander A, Öhman J, Iverson GL. Who gets recruited in mild traumatic brain injury research? Journal of Neurotrauma. 2013 tammi 1;30(1):11-16. https://doi.org/10.1089/neu.2012.2611

Author

Luoto, Teemu M. ; Tenovuo, Olli ; Kataja, Anneli ; Brander, Antti ; Öhman, Juha ; Iverson, Grant L. / Who gets recruited in mild traumatic brain injury research?. Julkaisussa: Journal of Neurotrauma. 2013 ; Vuosikerta 30, Nro 1. Sivut 11-16.

Bibtex - Lataa

@article{ff74ee33941846c6b2a6c5c17449dbb0,
title = "Who gets recruited in mild traumatic brain injury research?",
abstract = "Selection bias, common in traumatic brain injury research, limits the clinical usefulness and generalizability of study findings. The purpose of this study was to examine the effect of different inclusion and exclusion criteria on patient enrollment, and the implications for generalizability, in a mild traumatic brain injury (MTBI) study. The study was conducted at the emergency department (ED) of Tampere University Hospital. Our aim was to study outcome from MTBI in patients who do not have pre-existing conditions or other confounding factors. For this, all consecutive patients with acute head trauma (n=1344) were screened. The study design included three inclusion criteria and nine exclusion criteria. The World Health Organization Collaborating Center for Neurotrauma Task Force criteria for MTBI were used. Of all patients screened, 934 (69.5{\%}) fulfilled the MTBI criteria. For those fulfilling the MTBI criteria, various inclusion and exclusion criteria were applied in order to yield those eligible for the outcome study. Applying these criteria excluded 95.1{\%} of MTBI patients, leaving only 46 patients in the final sample. The final sample and the excluded patients with MTBI significantly differed in age, mechanism of injury, and injury severity characteristics. Many studies recruit fundamentally biased samples that are not generalizable to the population of persons who sustain an MTBI. Studying carefully selected samples is often necessary to address specific research questions, but such studies have serious limitations in terms of translating research findings into clinical practice.",
keywords = "head trauma, selection bias, traumatic brain injury",
author = "Luoto, {Teemu M.} and Olli Tenovuo and Anneli Kataja and Antti Brander and Juha {\"O}hman and Iverson, {Grant L.}",
year = "2013",
month = "1",
day = "1",
doi = "10.1089/neu.2012.2611",
language = "English",
volume = "30",
pages = "11--16",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "Mary Ann Liebert",
number = "1",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - Who gets recruited in mild traumatic brain injury research?

AU - Luoto, Teemu M.

AU - Tenovuo, Olli

AU - Kataja, Anneli

AU - Brander, Antti

AU - Öhman, Juha

AU - Iverson, Grant L.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Selection bias, common in traumatic brain injury research, limits the clinical usefulness and generalizability of study findings. The purpose of this study was to examine the effect of different inclusion and exclusion criteria on patient enrollment, and the implications for generalizability, in a mild traumatic brain injury (MTBI) study. The study was conducted at the emergency department (ED) of Tampere University Hospital. Our aim was to study outcome from MTBI in patients who do not have pre-existing conditions or other confounding factors. For this, all consecutive patients with acute head trauma (n=1344) were screened. The study design included three inclusion criteria and nine exclusion criteria. The World Health Organization Collaborating Center for Neurotrauma Task Force criteria for MTBI were used. Of all patients screened, 934 (69.5%) fulfilled the MTBI criteria. For those fulfilling the MTBI criteria, various inclusion and exclusion criteria were applied in order to yield those eligible for the outcome study. Applying these criteria excluded 95.1% of MTBI patients, leaving only 46 patients in the final sample. The final sample and the excluded patients with MTBI significantly differed in age, mechanism of injury, and injury severity characteristics. Many studies recruit fundamentally biased samples that are not generalizable to the population of persons who sustain an MTBI. Studying carefully selected samples is often necessary to address specific research questions, but such studies have serious limitations in terms of translating research findings into clinical practice.

AB - Selection bias, common in traumatic brain injury research, limits the clinical usefulness and generalizability of study findings. The purpose of this study was to examine the effect of different inclusion and exclusion criteria on patient enrollment, and the implications for generalizability, in a mild traumatic brain injury (MTBI) study. The study was conducted at the emergency department (ED) of Tampere University Hospital. Our aim was to study outcome from MTBI in patients who do not have pre-existing conditions or other confounding factors. For this, all consecutive patients with acute head trauma (n=1344) were screened. The study design included three inclusion criteria and nine exclusion criteria. The World Health Organization Collaborating Center for Neurotrauma Task Force criteria for MTBI were used. Of all patients screened, 934 (69.5%) fulfilled the MTBI criteria. For those fulfilling the MTBI criteria, various inclusion and exclusion criteria were applied in order to yield those eligible for the outcome study. Applying these criteria excluded 95.1% of MTBI patients, leaving only 46 patients in the final sample. The final sample and the excluded patients with MTBI significantly differed in age, mechanism of injury, and injury severity characteristics. Many studies recruit fundamentally biased samples that are not generalizable to the population of persons who sustain an MTBI. Studying carefully selected samples is often necessary to address specific research questions, but such studies have serious limitations in terms of translating research findings into clinical practice.

KW - head trauma

KW - selection bias

KW - traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=84871502735&partnerID=8YFLogxK

U2 - 10.1089/neu.2012.2611

DO - 10.1089/neu.2012.2611

M3 - Article

VL - 30

SP - 11

EP - 16

JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

IS - 1

ER -